Allosteric Influence of Extremophile Hairpin Motif Mutations on the Protein Splicing Activity of a Hyperthermophilic Intein.
Journal
Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623
Informations de publication
Date de publication:
07 07 2020
07 07 2020
Historique:
pubmed:
20
6
2020
medline:
24
2
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
Protein splicing is a post-translational process mediated by an intein, whereby the intein excises itself from a precursor protein with concomitant ligation of the two flanking polypeptides. The intein that interrupts the DNA polymerase II in the extreme hyperthermophile
Identifiants
pubmed: 32559373
doi: 10.1021/acs.biochem.0c00348
pmc: PMC7346874
mid: NIHMS1605854
doi:
Substances chimiques
Archaeal Proteins
0
DNA Polymerase II
EC 2.7.7.7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2459-2467Subventions
Organisme : NCI NIH HHS
ID : R01 CA206592
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM132817
Pays : United States
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