A novel

Ribosome structure and activity are challenged at high temperatures, often demanding modifications to ribosomal RNAs (rRNAs) to retain translation fidelity. LC-MS/MS, bisulfite-sequencing, and high-resolution cryo-EM structures of the archaeal ribosome identified an RNA modification,

Déclaration de conflit d'intérêts

Competing interests statement:K.A.F., P.S.H., V.T., L.E., J.S., H.P.F., R.C., and T.J.S. do not have any competing financial interests nor conflicts of interest to report. N.D., E.J.W., R.T.F., Y.-L.T., G.B.R., and I.R.C. are employed and funded by New England Biolabs, Inc., a manufacturer and vendor of molecular biology reagents, including nucleic acid modifying and synthesis enzymes. The authors state that this affiliation does not affect their impartiality, objectivity of data generation or interpretation, adherence to journal standards and policies, or availability of data.