Monocyclic β-Lactam: A Review on Synthesis and Potential Biological Activities of a Multitarget Core.
Antibiotic
anticancer
antiinflammatory
four membered heterocyclic ring
monocyclic β-lactam
pharmacological profile
Journal
Mini reviews in medicinal chemistry
ISSN: 1875-5607
Titre abrégé: Mini Rev Med Chem
Pays: Netherlands
ID NLM: 101094212
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
07
2019
revised:
08
01
2020
accepted:
20
04
2020
pubmed:
21
6
2020
medline:
20
5
2021
entrez:
21
6
2020
Statut:
ppublish
Résumé
A monocyclic ring in their structure characterizes monobactams, a subclass of β-lactam antibiotics. Many of these compounds have a bactericidal mechanism of action and acts as penicillin and cephalosporins, interfering with bacterial cell wall biosynthesis. The synthesis of novel β-lactams is an emerging area of organic synthesis research due to the problem of increasing bacterial resistance to existing β -lactam antibiotics, and, in this way, new compounds have been presented with several structural modifications, aiming to improve biological activities. Among the biological activities studied, the most outstanding are antibacterial, antitubercular, anticholesterolemic, anticancer, antiinflammatory, antiviral, and anti-enzymatic, among others. This review explores the vast number of works related to monocyclic β-lactams, compounds of great importance in scientific research.
Identifiants
pubmed: 32560602
pii: MRMC-EPUB-107459
doi: 10.2174/1389557520666200619114820
doi:
Substances chimiques
Anti-Infective Agents
0
Anti-Inflammatory Agents
0
Antineoplastic Agents
0
Antitubercular Agents
0
Monobactams
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1653-1682Informations de copyright
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