Factors influencing hepatitis C cure in the era of direct-acting antivirals.
Factores que influyen en la curación de la hepatitis C en la era de los antivirales de acción directa.
Adherence
Adherencia
Chronic hepatitis C
Cirrhosis
Cirrosis
Factores pronósticos
Genotipo
Genotype
Hepatitis crónica C
Prognostic factors
Respuesta viral
Sustained viral
response
sostenida
Journal
Gastroenterologia y hepatologia
ISSN: 0210-5705
Titre abrégé: Gastroenterol Hepatol
Pays: Spain
ID NLM: 8406671
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
pubmed:
21
6
2020
medline:
10
7
2020
entrez:
21
6
2020
Statut:
ppublish
Résumé
Direct-acting antiviral agents are highly potent drugs with a strong genetic barrier. Consequently, the factors influencing hepatitis C cure have been reduced and have progressively lost importance. Host factors, such as the presence of cirrhosis, race, and treatment adherence, influence sustained viral response. Adherence, together with treatment errors and drug interactions, are also important, especially in older patients. Viral factors, such as viral load, genotype, and the presence of baseline resistances affect the response rate but their influence can be minimised by using pan-genotypic regimens. Treatment simplification and the high efficacy of new antiviral treatments will allow treatment universalisation and will hopefully enable elimination of the infection in the next few decades. Supplement information: This article is part of a supplement entitled "The value of simplicity in hepatitis C treatment", which is sponsored by Gilead. © 2019 Elsevier España, S.L.U. All rights reserved.
Identifiants
pubmed: 32560767
pii: S0210-5705(20)30181-3
doi: 10.1016/S0210-5705(20)30181-3
pii:
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Langues
eng
spa
Sous-ensembles de citation
IM
Pagination
1-7Informations de copyright
Copyright © 2019 Elsevier España, S.L.U. Todos los derechos reservados.