Searching for autoimmune encephalitis: Beware of normal CSF.
Autoimmune diseases
Autoimmune encephalitis
Cerebrospinal fluid
Diagnostic studies
Encephalitis
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 08 2020
15 08 2020
Historique:
received:
14
01
2020
revised:
17
05
2020
accepted:
02
06
2020
pubmed:
21
6
2020
medline:
11
11
2020
entrez:
21
6
2020
Statut:
ppublish
Résumé
To determine the prevalence of cerebrospinal fluid (CSF) markers associated with inflammation (i.e., elevated white blood cell count, protein concentration, and CSF-specific oligoclonal bands) in patients with early active autoimmune encephalitis (AE). CSF characteristics, including WBC count, protein concentration, and oligoclonal banding, were analyzed in patients diagnosed with AE at two tertiary care centers. Ninety-five patients were included in the study. CSF white blood cell counts and protein levels were within normal limits for 27% (CI White blood cell counts and protein levels were within normal limits in the CSF of a substantial proportion of patients with early active AE. Inclusion of CSF oligoclonal banding identified a higher proportion of patients with an inflammatory CSF profile, especially when CSF was sampled early in the disease process.
Identifiants
pubmed: 32563126
pii: S0165-5728(20)30035-7
doi: 10.1016/j.jneuroim.2020.577285
pmc: PMC7376817
mid: NIHMS1604115
pii:
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577285Subventions
Organisme : NIA NIH HHS
ID : K23 AG064029
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Dr. Hébert reports no disclosures. Dr. Gros reports no disclosures. Dr. Lapointe reports no disclosures. Mrs. Amtashar reports no disclosures. Dr. Steriade receives research funding from Finding A Cure for Seizure and Epilepsy (FACES), UCB and the American Epilepsy Society. She serves as a consultant to the non-profit organization The Epilepsy Study Consortium. She has received compensation for serving on an advisory board for UCB. Dr. Maurice reports no disclosures. Dr. Wennberg reports no disclosures. Dr. Day has served as a topic editor on dementia for DynaMed Plus (EBSCO Industries, Inc) and as clinical director for the Anti-NMDA Receptor Encephalitis Foundation (uncompensated). He receives research/grant support from the National Institutes of Health (K23AG064029) and holds stock in ANI Pharmaceuticals, Inc. GSD has provided record review and expert medical testimony on legal cases pertaining to management of Wernicke encephalopathy. Dr. Tang-Wai reports no disclosures.
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