Sequential allogeneic hematopoietic stem cell transplantation for active refractory/relapsed myeloid malignancies: results of a reduced-intensity conditioning preceded by clofarabine and cytosine arabinoside, a retrospective study on behalf of the SFGM-TC.
Adolescent
Adult
Aged
Allografts
Antineoplastic Combined Chemotherapy Protocols
/ administration & dosage
Clofarabine
/ administration & dosage
Cytarabine
/ administration & dosage
Disease-Free Survival
Female
Hematopoietic Stem Cell Transplantation
Humans
Leukemia, Myeloid, Acute
/ mortality
Male
Middle Aged
Myelodysplastic Syndromes
/ mortality
Retrospective Studies
Survival Rate
Transplantation Conditioning
Acute myeloid leukemia
Allogeneic stem cell transplantation
Clofarabine
Reduced intensity conditioning regimen
Sequential regimen
Journal
Annals of hematology
ISSN: 1432-0584
Titre abrégé: Ann Hematol
Pays: Germany
ID NLM: 9107334
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
21
01
2020
accepted:
04
05
2020
pubmed:
22
6
2020
medline:
14
7
2020
entrez:
22
6
2020
Statut:
ppublish
Résumé
Allogeneic stem cell transplantation (allo-SCT) represents the most beneficial treatment for patients with active relapsed/refractory (R/R) hematologic malignancies. Recently, sequential regimens combining debulking chemotherapy followed by reduced-intensity conditioning (RIC) have shown encouraging results for these patients. In this retrospective study, we report the extended results of a sequential regimen of clofarabine, cytosine arabinoside, and RIC in 131 adults with active R/R myeloid disease at transplant. Conditioning consisted of clofarabine (30 mg/m
Identifiants
pubmed: 32564196
doi: 10.1007/s00277-020-04074-7
pii: 10.1007/s00277-020-04074-7
doi:
Substances chimiques
Cytarabine
04079A1RDZ
Clofarabine
762RDY0Y2H
Types de publication
Clinical Trial
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1855-1862Références
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