An association between the rs1799853 and rs1057910 polymorphisms of CYP2C9, the rs4244285 polymorphism of CYP2C19 and the prevalence rates of drug-resistant epilepsy in children.
CYP2
Drug-resistant epilepsy
gene
polymorphism
Journal
The International journal of neuroscience
ISSN: 1563-5279
Titre abrégé: Int J Neurosci
Pays: England
ID NLM: 0270707
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
pubmed:
23
6
2020
medline:
9
2
2022
entrez:
23
6
2020
Statut:
ppublish
Résumé
Epilepsy is a neurologically based disease. Literature data indicate a certain association between the polymorphism of these genes, which participate in the metabolism of drugs (CYP), and drug-resistant epilepsy. The reports describe studies in which an association was evaluated between the rs1799853 (430C > T) and rs1057910 (1075A > C) polymorphisms of The above-mentioned polymorphisms were assessed by the PCR-RFLP technique in a group of patients with drug-resistant ( It was demonstrated that CT genotype of the rs1799853 polymorphism of The obtained results indicated that the rs1799853 and rs1057910 polymorphisms of
Identifiants
pubmed: 32567426
doi: 10.1080/00207454.2020.1781110
doi:
Substances chimiques
CYP2C9 protein, human
EC 1.14.13.-
Cytochrome P-450 CYP2C9
EC 1.14.13.-
CYP2C19 protein, human
EC 1.14.14.1
Cytochrome P-450 CYP2C19
EC 1.14.14.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM