questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Hémoprotéines
Cytochromes
Cytochrome P-450 enzyme system
Famille-2 de cytochromes P450
Limonène hydroxylases
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2C9 : Questions médicales fréquentes
Diagnostic
5
Tests génétiques
Polymorphisme génétique
Effets indésirables
Réponse au traitement
Interactions médicamenteuses
Profil métabolique
Métabolisme hépatique
Analyses sanguines
Symptômes
5
Nausées
Réactions allergiques
Surdose
Douleurs abdominales
Effets secondaires
Efficacité des médicaments
Carence enzymatique
Effets indésirables
Toxicité médicamenteuse
Éruptions cutanées
Prévention
5
Prévention
Suivi régulier
Anticoagulants
Saignement
Interactions médicamenteuses
Information médicale
Tests préventifs
Complications
Sensibilisation
Tests génétiques
Traitements
5
Ajustement de dose
Tests génétiques
Gestion des interactions
Surveillance thérapeutique
Traitements alternatifs
Médicaments
Surdose
Soins symptomatiques
Complications
5
Complications
Réactions allergiques
Surdose
Dommages organiques
Gestion des complications
Surveillance étroite
Déficience enzymatique
Maladies chroniques
Interactions médicamenteuses
Hospitalisations
Facteurs de risque
5
Facteurs de risque
Génétique
Alimentation
Inhibition enzymatique
Antifongiques
Inhibition enzymatique
Maladies hépatiques
Métabolisme des médicaments
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}
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{
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"@type": "Question",
"name": "Quel rôle de l'alimentation sur CYP2C9 ?",
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}
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"position": 30,
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"text": "Les maladies hépatiques peuvent réduire l'activité de CYP2C9, affectant le métabolisme des médicaments."
}
}
]
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}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 29/03/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Rókus u. 2, Pécs H-7624, Hungary; Lab-on-a-Chip Research Group, János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, Pécs H-7624, Hungary. Electronic address: poor.miklos@pte.hu.
Publications dans "Cytochrome P-450 CYP2C9" :
In vitro interaction of potential antiviral TMPRSS2 inhibitors with human serum albumin and cytochrome P 450 isoenzymes.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2021-12-13
Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes, and organic anion-transporting polypeptides (OATP1B1 and OATP2B1).
Pharmacology research & perspectives
Interaction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and CYP3A4) enzymes and organic anion transporting polypeptide (OATP1B1 and OATP2B1) transporters.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2022-12-05
3 publications dans cette catégorie
Affiliations :
The Key laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P. R. China.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Rókus u. 2, Pécs H-7624, Hungary; Lab-on-a-Chip Research Group, János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, Pécs H-7624, Hungary.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Rókus u. 2, Pécs H-7624, Hungary; Lab-on-a-Chip Research Group, János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, Pécs H-7624, Hungary.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
The Key laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P. R. China.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Cardiovascular Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P. R. China.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, P.R. China.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, P.R. China.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, P.R. China.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Cardiovascular Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P. R. China.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Cardiovascular Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P. R. China.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
The Key laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P. R. China.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville, Florida, USA.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Federal University of Sao Joao del-Rei, Av. Sebastiao Goncalves Coelho, 400, Campus Centro-Oeste, Chanadour, Divinopolis-MG, CEP: 35501-296, Brazil.
Federal University of Minas Gerais, Av. Presidente Antonio Carlos, 667, Campus Pampulha, Belo Horizonte-MG, CEP: 31270-901, Brazil.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Federal University of Sao Joao del-Rei, Av. Sebastiao Goncalves Coelho, 400, Campus Centro-Oeste, Chanadour, Divinopolis-MG, CEP: 35501-296, Brazil.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Federal University of Sao Joao del-Rei, Av. Sebastiao Goncalves Coelho, 400, Campus Centro-Oeste, Chanadour, Divinopolis-MG, CEP: 35501-296, Brazil.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Federal University of Sao Joao del-Rei, Av. Sebastiao Goncalves Coelho, 400, Campus Centro-Oeste, Chanadour, Divinopolis-MG, CEP: 35501-296, Brazil.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Drug Resistance Research Group, Institute of Molecular Life Sciences, Research Centre for Natural Sciences, HUN-REN, Budapest, Hungary.
Doctoral School of Biology, Institute of Biology, Eötvös Loránd University, Budapest, Hungary.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.
Publications dans "Cytochrome P-450 CYP2C9" :
2 publications dans cette catégorie
Affiliations :
Drug Resistance Research Group, Institute of Molecular Life Sciences, Research Centre for Natural Sciences, HUN-REN, Budapest, Hungary.
Publications dans "Cytochrome P-450 CYP2C9" :
Bariatric surgeries are becoming more prevalent as obesity rates continue to rise. Being that it is an effective weight-loss procedure, it can induce significant anatomical, physiological, and metabol...
CYP2C9 is a member of the cytochrome P450 (CYP) superfamily responsible for the metabolism of 16% of drugs that undergo oxidative metabolism. The activity of CYP2C9 exhibits marked inter-individual va...
The purpose of the current study was to evaluate the ability of the PMR to predict the oral clearance of (S)-warfarin (SWOCL) and its formation clearance towards its CYP2C9-mediated metabolites (SWCLf...
The study was conducted in 150 healthy non-smoker subjects (segment 1) and 60 patients treated with warfarin (segment 2). In the first segment, the participants received on two separate occasions a si...
The PMR, SWOCL, and SWCLf varied significantly between carriers of different CYP2C9 genotypes in both healthy subjects (p < 0.001) and patients (p < 0.005). However, PMR and SWOCL values exhibited sub...
The PMR is the strongest predictor of SWOCL, and as such, it exhibits a significant advantage over the CYP2C9 genotype. The inclusion of PMR in future dosing algorithms of CYP2C9 substrates characteri...
Luteolin and naringenin are flavonoids found in various foods/beverages and present in certain dietary supplements. After a high intake of these flavonoids, their sulfate and glucuronide conjugates re...
Succinate dehydrogenase inhibitors (SDHIs) are widely-used fungicides, to which humans are exposed and for which putative health risks are of concern. In order to identify human molecular targets for ...
Ibuprofen, a common non-steroidal anti-inflammatory drug, is used clinically for pain relief and antipyretic treatment worldwide. However, regular or long-term use of ibuprofen may lead to a series of...
Thirty-eight recombinant human CYP2C9 microsomal enzymes were obtained using a frugiperda 21 insect expression system according to a previously described method. Assessment of the catalytic function o...
The intrinsic clearance (CL...
This is the first systematic evaluation of the catalytic characteristics of 38 CYP2C9 genotypes involved ibuprofen metabolism. Our results provide a corresponding supplement to studies on CYP2C9 gene ...
Juvenile myoclonic epilepsy (JME) is the most common of the generalized genetic epilepsies, with multiple causal and susceptibility genes; however, its etiopathogenesis is mainly unknown. The toxic ef...
1. Temperature is considered to affect the activity of drug-metabolizing enzymes; however, no previous studies have compared temperature dependency among cytochrome P450 genetic variants. This study a...
Genetic variability in the cytochrome P450 CYP2C9 constitutes an important predictor for efficacy and safety of various commonly prescribed drugs, including coumarin anticoagulants, phenytoin and mult...
Frequencies of eight functionally relevant CYP2C9 alleles (*2, *3, *5, *6, *8, *11, *13 and *14) were analyzed. In total, 108 original articles were identified that included genotype data from a total...
This study provides a comprehensive map of the genetic and functional variability of CYP2C9 with high ethnogeographic resolution. The presented data can serve as a useful resource for CYP2C9 allele an...
The aim of this study was to establish the physiologically based pharmacokinetic (PBPK) model of flurbiprofen related to CYP2C9 genetic polymorphism and describe the pharmacokinetics of flurbiprofen i...
To investigate the association of CYP2C9 metabolic phenotypes with phenytoin plasma concentration ([PTH]) in neurosurgical patients from the Brazilian Public Health System....
Patients (n = 170) were treated with phenytoin (300 mg/day) perioperatively as prophylaxis for postoperative seizures. Two to 10 days after surgery, a blood sample was collected for quantification of ...
Wide (22-fold) interindividual variation in [PTH] was observed (2.2-47.5 mg/l). [PTH] associated significantly (Kruskal-Wallis P < 0.005) with CYP2C9 phenotypes and there was a significant trend (Jonc...
Diplotype-predicted CYP2C9 metabolic phenotypes are associated significantly with [PTH] in neurosurgical Brazilian patients receiving phenytoin for postsurgery seizure prophylaxis. [PHT] increased pro...