Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets.

Anti-Bacterial Agents / chemistry Antineoplastic Agents / chemistry Biocatalysis Drug Discovery / methods Enzyme Inhibitors / chemistry Escherichia coli / drug effects Escherichia coli Infections / drug therapy Humans Molecular Docking Simulation Neoplasms / drug therapy Nucleotides / chemistry Oxidation-Reduction Protein Structure, Secondary Protein Subunits / antagonists & inhibitors Ribonucleotide Reductases / antagonists & inhibitors Small Molecule Libraries / chemistry Structure-Activity Relationship
mechanisms ribonucleotide reductases structures therapeutics

Journal

Annual review of biochemistry
ISSN: 1545-4509
Titre abrégé: Annu Rev Biochem
Pays: United States
ID NLM: 2985150R

Informations de publication

Date de publication:
20 06 2020
Historique:
entrez: 23 6 2020
pubmed: 23 6 2020
medline: 2 6 2021
Statut: ppublish

Résumé

Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing so, they play an important role in fidelity of DNA replication and repair. RNRs' central role in nucleic acid metabolism has resulted in five therapeutics that inhibit human RNRs. In this review, we discuss the structural, dynamic, and mechanistic aspects of RNR activity and regulation, primarily for the human and

Identifiants

DOI: 10.1146/annurev-biochem-013118-111843 PMID: 32569524 PMC: PMC7316142
pubmed: 32569524
doi: 10.1146/annurev-biochem-013118-111843
pmc: PMC7316142
mid: NIHMS1063546
doi:

Substances chimiques

Anti-Bacterial Agents 0
Antineoplastic Agents 0
Enzyme Inhibitors 0
Nucleotides 0
Protein Subunits 0
Small Molecule Libraries 0
Ribonucleotide Reductases EC 1.17.4.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

45-75

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM047274
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM126982
Pays : United States

Références

J Am Chem Soc. 2005 Jun 1;127(21):7729-38
pubmed: 15913363
DNA Repair (Amst). 2012 May 1;11(5):480-7
pubmed: 22417940
Curr Opin Struct Biol. 2008 Dec;18(6):650-7
pubmed: 19046875
J Inorg Biochem. 2011 Nov;105(11):1422-31
pubmed: 21955844
Mol Pharmacol. 2015 Jun;87(6):996-1005
pubmed: 25814515
Structure. 2012 Aug 8;20(8):1374-83
pubmed: 22727814
Nature. 1994 Dec 15;372(6507):695-8
pubmed: 7990963
Cancer Res. 2017 Sep 15;77(18):5068-5076
pubmed: 28754670
Bioorg Med Chem. 2019 Aug 1;27(15):3421-3439
pubmed: 31204229
Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8979-84
pubmed: 10430881
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3835-40
pubmed: 23431160
Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21046-51
pubmed: 22160671
Cell Metab. 2010 Oct 6;12(4):373-385
pubmed: 20889129
Nat Chem Biol. 2018 Oct;14(10):943-954
pubmed: 30150681
Adv Enzyme Regul. 2005;45:112-25
pubmed: 16054677
Drug Metab Rev. 2009;41(2):77-88
pubmed: 19514966
J Med Chem. 2008 Aug 14;51(15):4653-9
pubmed: 18610997
Genes (Basel). 2016 Nov 17;7(11):
pubmed: 27869662
Prog Biophys Mol Biol. 2001 Nov;77(3):177-268
pubmed: 11796141
J Enzyme Inhib Med Chem. 2019 Dec;34(1):438-450
pubmed: 30734609
Cancer Res. 1990 Jul 15;50(14):4417-22
pubmed: 2364394
Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):39-43
pubmed: 22171005
Mol Cell. 2009 Dec 11;36(5):845-60
pubmed: 20005847
Science. 2010 Sep 17;329(5998):1526-30
pubmed: 20688982
J Am Chem Soc. 2011 Nov 16;133(45):18420-32
pubmed: 21967342
Annu Rev Biochem. 2011;80:733-67
pubmed: 21456967
Mol Pharmacol. 2002 Jan;61(1):222-9
pubmed: 11752224
Biochemistry. 1999 Jan 26;38(4):1221-33
pubmed: 9930982
Chem Biol. 1995 Dec;2(12):793-801
pubmed: 8807812
Curr Opin Chem Biol. 2020 Feb;54:10-18
pubmed: 31734537
J Biol Chem. 1992 Jun 25;267(18):12622-6
pubmed: 1618767
Antioxid Redox Signal. 2019 Mar 10;30(8):1062-1082
pubmed: 29334758
Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14324-9
pubmed: 17726094
Structure. 2016 Jun 7;24(6):906-17
pubmed: 27133024
J Am Chem Soc. 2003 Dec 10;125(49):14988-9
pubmed: 14653724
Elife. 2016 Jan 12;5:e07141
pubmed: 26754917
J Am Chem Soc. 2016 Oct 19;138(41):13706-13716
pubmed: 28068088
Expert Rev Hematol. 2010 Feb;3(1):15-22
pubmed: 21082931
Mol Cancer Ther. 2007 Apr;6(4):1239-48
pubmed: 17406032
Cancer Res. 1996 Jul 1;56(13):3030-7
pubmed: 8674058
Proc Natl Acad Sci U S A. 2004 May 4;101(18):6882-7
pubmed: 15123822
Science. 1996 Jan 26;271(5248):477-81
pubmed: 8560260
Nature. 1990 Jun 14;345(6276):593-8
pubmed: 2190093
J Am Chem Soc. 2014 Nov 19;136(46):16210-6
pubmed: 25353063
Biochemistry. 1998 May 5;37(18):6419-26
pubmed: 9572859
Biochemistry. 2009 Dec 15;48(49):11612-21
pubmed: 19899807
Chem Rev. 1998 Apr 2;98(2):705-762
pubmed: 11848913
Nature. 1994 Aug 18;370(6490):533-9
pubmed: 8052308
Biochemistry. 2006 Oct 10;45(40):12282-94
pubmed: 17014081
PLoS Genet. 2018 Nov 19;14(11):e1007462
pubmed: 30452489
Biochemistry. 2001 Aug 14;40(32):9631-7
pubmed: 11583163
Blood Adv. 2018 May 22;2(10):1157-1169
pubmed: 29789314
Bioorg Med Chem. 2014 Apr 1;22(7):2303-10
pubmed: 24588962
Sci Rep. 2016 Jul 11;6:29361
pubmed: 27405729
J Cancer Res Clin Oncol. 2017 Aug;143(8):1499-1529
pubmed: 28624910
Biochim Biophys Acta. 1995 Mar 15;1247(2):215-24
pubmed: 7696311
Nat Commun. 2017 Aug 14;8(1):241
pubmed: 28808226
Elife. 2018 Feb 20;7:
pubmed: 29460780
J Biol Chem. 2014 Feb 28;289(9):6259-72
pubmed: 24381172
Nat Commun. 2019 Jun 14;10(1):2653
pubmed: 31201319
J Biol Chem. 2018 Jun 29;293(26):10404-10412
pubmed: 29700111
Free Radic Biol Med. 2014 Jan;66:75-87
pubmed: 23899494
Nat Rev Drug Discov. 2006 Oct;5(10):855-63
pubmed: 17016426
Annu Rev Biochem. 1998;67:71-98
pubmed: 9759483
J Biol Chem. 1973 Nov 10;248(21):7464-72
pubmed: 4355582
Biochemistry. 2008 Apr 1;47(13):3989-99
pubmed: 18314964
Oncotarget. 2016 Jan 12;7(2):1984-99
pubmed: 26675256
Nature. 1986 May 22-28;321(6068):439-41
pubmed: 3012359
Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10022-10027
pubmed: 30224458
Chem Biol. 2012 Jul 27;19(7):799-805
pubmed: 22840768
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2723-4
pubmed: 9501154
Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1695-704
pubmed: 24733891
Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9815-20
pubmed: 21628579
J Biol Chem. 1976 Mar 10;251(5):1398-405
pubmed: 767333
Cancer Res. 1994 Mar 15;54(6):1485-90
pubmed: 8137252
J Med Chem. 1995 Sep 1;38(18):3617-23
pubmed: 7658449
Biochemistry. 2003 Sep 2;42(34):10071-83
pubmed: 12939135
ACS Chem Biol. 2016 Jul 15;11(7):2021-32
pubmed: 27159113
Biochemistry. 2010 Jun 29;49(25):5340-9
pubmed: 20462199
Annu Rev Biochem. 2006;75:681-706
pubmed: 16756507
Biochemistry. 2009 Dec 15;48(49):11622-9
pubmed: 19899770
J Am Chem Soc. 2017 Mar 1;139(8):2994-3004
pubmed: 28171730
Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4594-E4603
pubmed: 29712847
J Med Chem. 1991 Jun;34(6):1879-84
pubmed: 2061926
Crit Rev Biochem Mol Biol. 2012 Jan-Feb;47(1):50-63
pubmed: 22050358
Nat Struct Mol Biol. 2011 Mar;18(3):316-22
pubmed: 21336276
J Biol Chem. 2019 Feb 8;294(6):1763-1778
pubmed: 30573684
J Biol Chem. 1983 Jul 10;258(13):8060-7
pubmed: 6305969
Biochem Biophys Res Commun. 1992 Oct 30;188(2):879-87
pubmed: 1332707
Nature. 2018 Nov;563(7731):416-420
pubmed: 30429545
Biochemistry. 2016 Jan 19;55(2):373-81
pubmed: 26727048
Biochem Biophys Res Commun. 2011 Sep 23;413(2):383-8
pubmed: 21893046
Biochemistry. 2019 Feb 12;58(6):435-437
pubmed: 30586288
J Biol Chem. 2017 Jun 2;292(22):9229-9239
pubmed: 28377505
Int J Clin Oncol. 2017 Aug;22(4):619-628
pubmed: 28643177
Semin Oncol. 1996 Oct;23(5 Suppl 10):3-15
pubmed: 8893876
Acc Chem Res. 2013 Nov 19;46(11):2524-35
pubmed: 23730940
Biochemistry. 1991 May 28;30(21):5164-71
pubmed: 2036382
Nature. 1986 May 22-28;321(6068):441-3
pubmed: 3012360
Cancer Res. 2013 Nov 1;73(21):6484-93
pubmed: 24072748
Semin Cell Dev Biol. 2014 Jun;30:97-103
pubmed: 24704278
Cancer Res. 1995 Jul 1;55(13):2847-52
pubmed: 7540950
J Biol Chem. 2012 Oct 12;287(42):35768-78
pubmed: 22915594
J Am Chem Soc. 2007 Dec 26;129(51):15748-9
pubmed: 18047343
Biochemistry. 2014 Feb 4;53(4):766-76
pubmed: 24401092
J Biol Chem. 1980 Sep 10;255(17):8027-30
pubmed: 6997288
Oncogene. 2015 Apr 16;34(16):2011-21
pubmed: 24909171
Biochemistry. 1996 Jun 25;35(25):8381-91
pubmed: 8679596
Biochemistry. 1992 May 26;31(20):4801-7
pubmed: 1591241
J Biol Chem. 2017 Jun 2;292(22):9136-9149
pubmed: 28411237
Curr Opin Chem Biol. 2011 Apr;15(2):284-90
pubmed: 21216656
Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8241-8246
pubmed: 28716944
Oncogene. 2008 Oct 27;27(50):6522-37
pubmed: 18955977

Auteurs

Brandon L Greene (BL)

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email: stubbe@mit.edu.
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Gyunghoon Kang (G)

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email: stubbe@mit.edu.

Chang Cui (C)

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email: stubbe@mit.edu.
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Marina Bennati (M)

Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
Department of Chemistry, University of Göttingen, 37073 Göttingen, Germany.

Daniel G Nocera (DG)

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Catherine L Drennan (CL)

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email: stubbe@mit.edu.
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

JoAnne Stubbe (J)

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email: stubbe@mit.edu.
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Métabolisme › Biocatalyse › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections à Escherichia coli › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Tumeurs › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Sous-unités de protéines › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Ribonucleotide reductases › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Bibliothèques de petites molécules › Ribonucleotide Reductases: Structure,...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Ribonucleotide Reductases: Structure,...