Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A
Adenosine A2 Receptor Antagonists
/ chemical synthesis
Animals
CHO Cells
Cell Line, Tumor
Cricetulus
Cytochrome P-450 CYP2D6 Inhibitors
/ chemical synthesis
Cytochrome P-450 CYP3A Inhibitors
/ chemical synthesis
Humans
Imidazoles
/ chemical synthesis
Molecular Docking Simulation
Molecular Structure
Pyrimidines
/ chemical synthesis
Receptor, Adenosine A2B
/ metabolism
Stereoisomerism
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
23 07 2020
23 07 2020
Historique:
pubmed:
24
6
2020
medline:
15
12
2020
entrez:
24
6
2020
Statut:
ppublish
Résumé
A systematic exploration of bioisosteric replacements for furan and thiophene cores in a series of potent A
Identifiants
pubmed: 32573250
doi: 10.1021/acs.jmedchem.0c00564
doi:
Substances chimiques
ADORA2B protein, human
0
Adenosine A2 Receptor Antagonists
0
Cytochrome P-450 CYP2D6 Inhibitors
0
Cytochrome P-450 CYP3A Inhibitors
0
Imidazoles
0
Pyrimidines
0
Receptor, Adenosine A2B
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM