Prevalence of Sars-Cov-2 Infection in Health Workers (HWs) and Diagnostic Test Performance: The Experience of a Teaching Hospital in Central Italy.
Adult
Aged
Betacoronavirus
/ isolation & purification
COVID-19
COVID-19 Testing
Clinical Laboratory Techniques
/ statistics & numerical data
Coronavirus Infections
/ diagnosis
Cross-Sectional Studies
Female
Health Personnel
/ statistics & numerical data
Health Workforce
Hospitals, Teaching
/ statistics & numerical data
Humans
Italy
/ epidemiology
Male
Middle Aged
Pandemics
Pneumonia, Viral
/ diagnosis
Polymerase Chain Reaction
Prevalence
Retrospective Studies
SARS-CoV-2
Time Factors
Young Adult
CoViD-19
health workers (HWs), screening
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
19 06 2020
19 06 2020
Historique:
received:
27
05
2020
revised:
15
06
2020
accepted:
17
06
2020
entrez:
25
6
2020
pubmed:
25
6
2020
medline:
3
7
2020
Statut:
epublish
Résumé
(1) Background: Health workers (HWs) are at high risk of acquiring SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infections. Therefore, health authorities further recommend screening strategies for SARS-CoV-2 infection in exposed or high-risk HWs. Nevertheless, to date, the best/optimal method to screen HWs for SARS-CoV-2 infection is still under debate, and data on the prevalence of SARS-CoV-2 infection in HWs are still scarce. The present study aims to assess the SARS-CoV-2 infection rate amongst HWs in a teaching hospital in Central Italy and the diagnostic performance of SARS-CoV-2 serology (index test) in comparison with the SARS-CoV-2 RNA PCR assay (reference standard). (2) Methods: A cross-sectional study on the retrospective data of HWs tested for SARS-CoV-2 by RNA-RT-PCR on nasopharyngeal swabs and by an IgM/IgG serology assay on venous blood samples, irrespective of exposure and/or symptoms, was carried out. (3) Results: A total of 2057 HWs (median age 46, 19-69 years, females 60.2%) were assessed by the RNA RT-PCR assay and 58 (2.7%) tested positive for SARS-CoV-2 infection. Compared with negative HWs, SARS-CoV-2-positives were younger (mean age 41.7 versus 45.2,
Identifiants
pubmed: 32575505
pii: ijerph17124417
doi: 10.3390/ijerph17124417
pmc: PMC7345358
pii:
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Clin Chem. 2020 Aug 1;66(8):1055-1062
pubmed: 32402061
Clin Infect Dis. 2020 Nov 19;71(16):2218-2221
pubmed: 32179890
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Nat Med. 2020 Jun;26(6):845-848
pubmed: 32350462
Euro Surveill. 2020 Mar;25(12):
pubmed: 32234115
Euro Surveill. 2015 Feb 19;20(7):29-38
pubmed: 25719965
JAMA Netw Open. 2020 May 1;3(5):e209666
pubmed: 32437575
Acad Emerg Med. 2020 Jun;27(6):469-474
pubmed: 32396670
Lancet. 2020 Mar 21;395(10228):922
pubmed: 32199474
Aliment Pharmacol Ther. 2020 May;51(9):843-851
pubmed: 32222988
BMJ Open. 2016 Nov 14;6(11):e012799
pubmed: 28137831
Clin Chem. 2020 Jul 1;66(7):875-877
pubmed: 32343775
Science. 2020 Jun 5;368(6495):1060-1061
pubmed: 32414781
Ann Intern Med. 2020 Jul 21;173(2):120-136
pubmed: 32369541
J Clin Pathol. 2020 Jul;73(7):370-377
pubmed: 32404473
PLoS Med. 2007 Oct 16;4(10):e297
pubmed: 17941715
Int J Environ Res Public Health. 2020 May 02;17(9):
pubmed: 32370116
Lancet. 2020 Feb 15;395(10223):470-473
pubmed: 31986257
Disaster Med Public Health Prep. 2020 Jun;14(3):372-376
pubmed: 32207676
J Infect. 2020 Aug;81(2):e91-e92
pubmed: 32417311
J Clin Microbiol. 2020 Jul 23;58(8):
pubmed: 32381641
Infect Control Hosp Epidemiol. 2020 May 15;:1-2
pubmed: 32408922
Ann Intern Med. 2020 Jun 2;172(11):766-767
pubmed: 32176257
J Clin Microbiol. 2020 Jul 23;58(8):
pubmed: 32350047
Elife. 2020 May 11;9:
pubmed: 32392129
J Clin Virol. 2020 Jul;128:104437
pubmed: 32434708
Int J Environ Res Public Health. 2014 Aug 20;11(8):8529-41
pubmed: 25140999
J Hosp Infect. 2020 May;105(1):100-101
pubmed: 32147406
J Occup Environ Med. 2020 Jul;62(7):e373-e376
pubmed: 32730043