Development of Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer: An Update.
albumin binding domain
glypican-3
hepatocellular carcinoma
recombinant immunotoxin
single-domain antibody
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
20 06 2020
20 06 2020
Historique:
received:
31
05
2020
revised:
17
06
2020
accepted:
18
06
2020
entrez:
25
6
2020
pubmed:
25
6
2020
medline:
13
4
2021
Statut:
epublish
Résumé
Hepatocellular carcinoma (HCC) accounts for most liver cancers and represents one of the deadliest cancers in the world. Despite the global demand for liver cancer treatments, there remain few options available. The U.S. Food and Drug Administration (FDA) recently approved Lumoxiti, a CD22-targeting immunotoxin, as a treatment for patients with hairy cell leukemia. This approval helps to demonstrate the potential role that immunotoxins can play in the cancer therapeutics pipeline. However, concerns have been raised about the use of immunotoxins, including their high immunogenicity and short half-life, in particular for treating solid tumors such as liver cancer. This review provides an overview of recent efforts to develop a glypican-3 (GPC3) targeting immunotoxin for treating HCC, including strategies to deimmunize immunotoxins by removing B- or T-cell epitopes on the bacterial toxin and to improve the serum half-life of immunotoxins by incorporating an albumin binding domain.
Identifiants
pubmed: 32575752
pii: biom10060934
doi: 10.3390/biom10060934
pmc: PMC7356171
pii:
doi:
Substances chimiques
Bacterial Toxins
0
Glypicans
0
Immunotoxins
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Intramural NIH HHS
ID : Z01 BC010891
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA BC010891
Pays : United States
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