Safety margins for dermatofibrosarcoma protuberans: a comparison between wide local excision and Mohs Tubingen technique.


Journal

European journal of dermatology : EJD
ISSN: 1952-4013
Titre abrégé: Eur J Dermatol
Pays: France
ID NLM: 9206420

Informations de publication

Date de publication:
01 Jun 2020
Historique:
pubmed: 25 6 2020
medline: 5 5 2021
entrez: 25 6 2020
Statut: ppublish

Résumé

Dermatofibrosarcoma protuberans (DFSP) is a rare, locally infiltrating, rarely metastasizing, soft tissue tumour. Due to its indistinct margins, local aggressive behaviour and high recurrence rate, the surgical approach is complex. Micrographic surgery and variants of this technique, e.g. Tubingen torte technique (TTT), should be considered as first-line treatment. To confirm that TTT is a safe and tissue-sparing technique, relative to theoretical wide local excision (WLE), for the same lesions, as recommended by the guidelines in the literature. Seventeen patients with histologically confirmed DFSP, treated with TTT between September 2014 and February 2019, were retrospectively analysed. For each patient, the final TTT excision area was calculated and compared with the theoretical equivalent area based on WLE. The difference in area was calculated and presented as percentage difference of preserved healthy skin based on the two approaches. In our patients, the mean preoperative lesion size was 4.55 ± 5.34 cm In our experience, TTT remains a safe, effective and tissue-sparing treatment for DFSP patients, especially when it is essential to spare tissue and in challenging locations.

Sections du résumé

BACKGROUND BACKGROUND
Dermatofibrosarcoma protuberans (DFSP) is a rare, locally infiltrating, rarely metastasizing, soft tissue tumour. Due to its indistinct margins, local aggressive behaviour and high recurrence rate, the surgical approach is complex. Micrographic surgery and variants of this technique, e.g. Tubingen torte technique (TTT), should be considered as first-line treatment.
OBJECTIVES OBJECTIVE
To confirm that TTT is a safe and tissue-sparing technique, relative to theoretical wide local excision (WLE), for the same lesions, as recommended by the guidelines in the literature.
MATERIALS AND METHODS METHODS
Seventeen patients with histologically confirmed DFSP, treated with TTT between September 2014 and February 2019, were retrospectively analysed. For each patient, the final TTT excision area was calculated and compared with the theoretical equivalent area based on WLE. The difference in area was calculated and presented as percentage difference of preserved healthy skin based on the two approaches.
RESULTS RESULTS
In our patients, the mean preoperative lesion size was 4.55 ± 5.34 cm
CONCLUSION CONCLUSIONS
In our experience, TTT remains a safe, effective and tissue-sparing treatment for DFSP patients, especially when it is essential to spare tissue and in challenging locations.

Identifiants

pubmed: 32576543
pii: ejd.2020.3771
doi: 10.1684/ejd.2020.3771
doi:

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

289-293

Auteurs

Edoardo Cammarata (E)

Department of Health Science, University of Eastern Piedmont, Novara.

Elia Esposto (E)

Department of Health Science, University of Eastern Piedmont, Novara.

Federica Veronese (F)

AOU Maggiore della Carità, Novara.

Chiara Airoldi (C)

Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.

Elisa Zavattaro (E)

Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.

Paolo Boggio (P)

AOU Maggiore della Carità, Novara.

Paola Savoia (P)

Department of Health Science, University of Eastern Piedmont, Novara.

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Classifications MeSH