Short-term exposure to air pollution (PM
Adipocytes, Brown
/ metabolism
Air Pollution
/ adverse effects
Animals
Energy Metabolism
/ drug effects
Gene Expression
Hyperphagia
/ etiology
Hypothalamus
/ drug effects
I-kappa B Kinase
/ genetics
Inflammation
/ etiology
Leptin
/ metabolism
Mice, Transgenic
Microglia
/ drug effects
Obesity
/ etiology
Particulate Matter
/ adverse effects
Signal Transduction
/ drug effects
Time Factors
Toll-Like Receptor 4
/ genetics
Uncoupling Protein 1
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 06 2020
23 06 2020
Historique:
received:
16
12
2019
accepted:
18
05
2020
entrez:
25
6
2020
pubmed:
25
6
2020
medline:
16
1
2021
Statut:
epublish
Résumé
A previous study demonstrated that a high-fat diet (HFD), administered for one-three-days, induces hypothalamic inflammation before obesity's established, and the long term affects leptin signaling/action due to inflammation. We investigate whether exposure to particulate matter of a diameter of ≤2.5 μm (PM
Identifiants
pubmed: 32576879
doi: 10.1038/s41598-020-67040-3
pii: 10.1038/s41598-020-67040-3
pmc: PMC7311527
doi:
Substances chimiques
Leptin
0
Particulate Matter
0
Tlr4 protein, mouse
0
Toll-Like Receptor 4
0
Ucp1 protein, mouse
0
Uncoupling Protein 1
0
I-kappa B Kinase
EC 2.7.11.10
Ikbke protein, mouse
EC 2.7.11.10
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10160Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK106076
Pays : United States
Références
Block, M. L. & Calderón-Garcidueñas, L. Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci. 32, 506–16 (2009).
pubmed: 19716187
pmcid: 2743793
doi: 10.1016/j.tins.2009.05.009
Landrigan, P. J. et al. The Lancet Commission on pollution and health. Lancet 391, 462–512 (2018).
pubmed: 29056410
doi: 10.1016/S0140-6736(17)32345-0
Perera, F. P. Multiple Threats to Child Health from Fossil Fuel Combustion: Impacts of Air Pollution and Climate Change. Environ. Health Perspect. 125, 141–148 (2017).
pubmed: 27323709
doi: 10.1289/EHP299
Milojevic, A. et al. Short-term effects of air pollution on a range of cardiovascular events in England and Wales: case-crossover analysis of the MINAP database, hospital admissions and mortality. Heart 100, 1093–1098 (2014).
pubmed: 24952943
pmcid: 4078678
doi: 10.1136/heartjnl-2013-304963
Alderete, T. L. et al. Longitudinal associations between ambient air pollution with insulin sensitivity, beta;-cell function, and adiposity in Los Angeles Latino Children. Diabetes 66, 1789–1796 (2017).
pubmed: 28137791
pmcid: 5482082
doi: 10.2337/db16-1416
Meo, S. A. et al. Effect of environmental air pollution on type 2 diabetes mellitus. Eur. Rev. Med. Pharmacol. Sci. 19, 123–128 (2015).
pubmed: 25635985
Pearson, J. F., Bachireddy, C., Shyamprasad, S., Goldfine, A. B. & Brownstein, J. S. Association between fine particulate matter and diabetes prevalence in the U.S. Diabetes Care 33, 2196–2201 (2010).
pubmed: 20628090
pmcid: 2945160
doi: 10.2337/dc10-0698
Cho, C. C. et al. In vitro and in vivo experimental studies of PM 2.5 on disease progression. Int. J. Environ. Res. Public Health 15, 1–26 (2018).
Liu, C., Ying, Z., Harkema, J., Sun, Q. & Rajagopalan, S. Epidemiological and experimental links between air pollution and type 2 diabetes. Toxicol. Pathol. 41, 361–373 (2013).
pubmed: 23104765
doi: 10.1177/0192623312464531
Liu, C. et al. Air pollution-mediated susceptibility to inflammation and insulin resistance: Influence of CCR2 pathways in mice. Environ. Health Perspect. 122, 17–26 (2014).
pubmed: 24149114
doi: 10.1289/ehp.1306841
Liu, C. et al. Particulate Air pollution mediated effects on insulin resistance in mice are independent of CCR2. Part. Fibre Toxicol. 14, 1–13 (2017).
doi: 10.1186/s12989-017-0187-3
Pan, W. W. & Myers, M. G. Leptin and the maintenance of elevated body weight. Nat. Rev. Neurosci. 19, 95–105 (2018).
pubmed: 29321684
doi: 10.1038/nrn.2017.168
Prada, P. O. et al. Western diet modulates insulin signaling, c-jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology 146, 1576–1587 (2005).
pubmed: 15591151
doi: 10.1210/en.2004-0767
Timper, K. & Brüning, J. C. Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Dis. Model. Mech. 10, 679–689 (2017).
pubmed: 28592656
pmcid: 5483000
doi: 10.1242/dmm.026609
Thaler, J. P. et al. Obesity is associated with hypothalamic injury in rodents and humans. J. Clin. Invest. 122, 153–162 (2012).
pubmed: 22201683
doi: 10.1172/JCI59660
Liu, C. et al. Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes. Part. Fibre Toxicol. 11, 1–16 (2014).
doi: 10.1186/1743-8977-11-1
Sun, Q. et al. Central IKK2 inhibition ameliorates air pollution- mediated hepatic glucose and lipid metabolism dysfunction in mice with type II diabetes. Toxicol. Sci. 164, 240–249 (2018).
pubmed: 29635361
pmcid: 6016715
doi: 10.1093/toxsci/kfy079
Larabee, C. M., Neely, O. C. & Domingos, A. I. Obesity: a neuroimmunometabolic perspective. Nat. Rev. Endocrinol. 16, 30–43 (2020).
pubmed: 31776456
doi: 10.1038/s41574-019-0283-6
Guilherme, A., Henriques, F., Bedard, A. H. & Czech, M. P. Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus. Nat. Rev. Endocrinol. 15, 207–225 (2019).
pubmed: 30733616
pmcid: 7073451
doi: 10.1038/s41574-019-0165-y
Shi, H. et al. TLR4 links innate immunity and fatty acid – induced insulin resistance Find the latest version: TLR4 links innate immunity and fatty acid – induced insulin resistance. J. Clin. Invest. 116, 3015–3025 (2006).
pubmed: 17053832
pmcid: 1616196
doi: 10.1172/JCI28898
Poggi, M. et al. C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia 50, 1267–1276 (2007).
pubmed: 17426960
doi: 10.1007/s00125-007-0654-8
Milanski, M. et al. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes 61, 1455–1462 (2012).
pubmed: 22522614
pmcid: 3357298
doi: 10.2337/db11-0390
Benomar, Y. & Taouis, M. Molecular Mechanisms Underlying Obesity-Induced Hypothalamic Inflammation and Insulin Resistance: Pivotal Role of Resistin/TLR4 Pathways. Front. Endocrinol. (Lausanne). 10, 1–10 (2019).
doi: 10.3389/fendo.2019.00140
Molteni, M., Gemma, S. & Rossetti, C. The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation. Mediators Inflamm. 2016, (2016).
Ivashkiv, L. B. & Donlin, L. T. Regulation of type I interferon responses. Nat. Rev. Immunol. 14, 36–49 (2014).
pubmed: 24362405
pmcid: 4084561
doi: 10.1038/nri3581
Kleinridders, A. et al. MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity. Cell Metab. 10, 249–259 (2009).
pubmed: 19808018
pmcid: 3898351
doi: 10.1016/j.cmet.2009.08.013
Zhang, X. et al. Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity. Cell 135, 61–73 (2008).
pubmed: 18854155
pmcid: 2586330
doi: 10.1016/j.cell.2008.07.043
Weissmann, L. et al. IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity. Diabetes 63, 3334–3345 (2014).
pubmed: 24812431
doi: 10.2337/db13-1817
Hu, Z. et al. Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5. Toxicology 390, 100–108 (2017).
pubmed: 28917655
pmcid: 5831254
doi: 10.1016/j.tox.2017.09.009
Ježek, P., Jabůrek, M. & Porter, R. K. Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1). Biochim. Biophys. acta. Bioenerg. 1860, 259–269 (2019).
pubmed: 30414927
doi: 10.1016/j.bbabio.2018.11.007
Morrison, S., Madden, C. & Tupone, D. Central Control of Brown Adipose Tissue Thermogenesis. Frontiers in Endocrinology 3, 5 (2012).
pmcid: 3292175
doi: 10.3389/fendo.2012.00005
Collins, S. β-Adrenoceptor Signaling Networks in Adipocytes for Recruiting Stored Fat and Energy Expenditure. Front. Endocrinol. (Lausanne). 2, 102 (2011).
pubmed: 22654837
doi: 10.3389/fendo.2011.00102
Balkwill, F. Tumour necrosis factor and cancer. Nat. Rev. Cancer 9, 361–371 (2009).
pubmed: 19343034
doi: 10.1038/nrc2628
Chu, W.-M. Tumor necrosis factor. Cancer Lett. 328, 222–225 (2013).
pubmed: 23085193
doi: 10.1016/j.canlet.2012.10.014
Dergham, M. et al. Prooxidant and proinflammatory potency of air pollution particulate matter (PM
pubmed: 22404339
doi: 10.1021/tx200529v
Calderón-Garcidueñas, L. et al. Air pollution and brain damage. Toxicol. Pathol. 30, 373–389 (2002).
pubmed: 12051555
doi: 10.1080/01926230252929954
Calderón-Garcidueñas, L. et al. Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants. Am. J. Respir. Cell Mol. Biol. 24, 132–138 (2001).
pubmed: 11159046
doi: 10.1165/ajrcmb.24.2.4157
Calderón-Garcidueñas, L. et al. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and you. Toxicol. Pathol. 36, 289–310 (2008).
pubmed: 18349428
doi: 10.1177/0192623307313011
Calderón-Garcidueñas, L. et al. DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration. Toxicol. Pathol. 31, 524–538 (2003).
pubmed: 14692621
doi: 10.1080/01926230390226645
Calderón-Garcidueñas, L., Reynoso-Robles, R. & González-Maciel, A. Combustion and friction-derived nanoparticles and industrial-sourced nanoparticles: The culprit of Alzheimer and Parkinson’s diseases. Environ. Res. 176, 108574 (2019).
pubmed: 31299618
doi: 10.1016/j.envres.2019.108574
Calderón-Garcidueñas, L. et al. Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology. Toxicol. Pathol. 35, 154–162 (2007).
pubmed: 17325984
doi: 10.1080/01926230601059985
Chen, M. et al. Concentrated Ambient PM(2.5)-Induced Inflammation and Endothelial Dysfunction in a Murine Model of Neural IKK2 Deficiency. Environ. Health Perspect. 126, 27003 (2018).
doi: 10.1289/EHP2311
Kim, F. et al. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ. Res. 100, 1589–1596 (2007).
pubmed: 17478729
doi: 10.1161/CIRCRESAHA.106.142851
Yoda, Y., Tamura, K. & Shima, M. Airborne endotoxin concentrations in indoor and outdoor particulate matter and their predictors in an urban city. Indoor Air 27, 955–964 (2017).
pubmed: 28161889
doi: 10.1111/ina.12370
Conde, J. et al. An update on leptin as immunomodulator. Expert Rev. Clin. Immunol. 10, 1165–1170 (2014).
pubmed: 25098336
doi: 10.1586/1744666X.2014.942289
Gan, L. et al. TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism. Endocrinology 153, 5821–5833 (2012).
pubmed: 23070544
pmcid: 3512064
doi: 10.1210/en.2012-1510
Calderón-Garcidueñas, L. et al. Mexico City normal weight children exposed to high concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and Alzheimer dis. Environ. Res. 140, 579–592 (2015).
pubmed: 26037109
doi: 10.1016/j.envres.2015.05.012
Chiang, S. H. et al. The Protein Kinase IKKε Regulates Energy Balance in Obese Mice. Cell 138, 961–975 (2009).
pubmed: 19737522
pmcid: 2756060
doi: 10.1016/j.cell.2009.06.046
Wada, T. et al. Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes. Am. J. Physiol. Metab. 300, E1112–E1123 (2011).
Münzberg, H., Flier, J. S. & Bjørbaek, C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145, 4880–4889 (2004).
pubmed: 15271881
doi: 10.1210/en.2004-0726
Flak, J. N. & Myers, M. G. Jr Minireview: CNS Mechanisms of Leptin Action. Mol. Endocrinol. 30, 3–12 (2016).
pubmed: 26484582
doi: 10.1210/me.2015-1232
de Barros Mendes Lopes, T. et al. Pre- and postnatal exposure of mice to concentrated urban PM(2.5) decreases the number of alveoli and leads to altered lung function at an early stage of life. Environ. Pollut. 241, 511–520 (2018).
pubmed: 29883952
pmcid: 6407120
doi: 10.1016/j.envpol.2018.05.055
Yoshizaki, K. et al. The effects of urban particulate matter on the nasal epithelium by gender: An experimental study in mice. Environ. Pollut. 213, 359–369 (2016).
pubmed: 26942683
doi: 10.1016/j.envpol.2016.02.044
Andrade, M. et al. Vehicle emissions and PM(2.5) mass concentrations in six Brazilian cities. Air Qual. Atmos. Health 5, 79–88 (2012).
pubmed: 22408695
doi: 10.1007/s11869-010-0104-5
de Miranda, R. M. et al. Urban air pollution: a representative survey of PM(2.5) mass concentrations in six Brazilian cities. Air Qual. Atmos. Health 5, 63–77 (2012).
pubmed: 22408694
doi: 10.1007/s11869-010-0124-1
Mauad, T. et al. Chronic exposure to ambient levels of urban particles affects mouse lung development. Am. J. Respir. Crit. Care Med. 178, 721–728 (2008).
pubmed: 18596224
pmcid: 2556454
doi: 10.1164/rccm.200803-436OC
Quaresma, P. G. F. et al. Cdc2-like kinase 2 in the hypothalamus is necessary to maintain energy homeostasis. Int. J. Obes. 41, (2017).
Quaresma, P. G. F. et al. Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway. Int. J. Obes. 40, 138–146 (2016).
doi: 10.1038/ijo.2015.134
Caricilli, A. M. et al. Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice. Endocrinology 153, (2012).
Zaafar, D. K., Zaitone, S. A. & Moustafa, Y. M. Role of metformin in suppressing 1,2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: Effect on tumor angiogenesis and cell proliferation. PLoS One 9, 1–12 (2014).
Bence, K. K. et al. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat. Med. 12, 917–924 (2006).
pubmed: 16845389
doi: 10.1038/nm1435
Furigo, I. C. et al. Brain STAT5 signaling modulates learning and memory formation. Brain Struct. Funct. 223, 2229–2241 (2018).
pubmed: 29460051
doi: 10.1007/s00429-018-1627-z