Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
07 Dec 2020
Historique:
pubmed: 25 6 2020
medline: 25 6 2020
entrez: 25 6 2020
Statut: epublish

Résumé

The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the associated disease COVID-19, requires therapeutic interventions that can be rapidly identified and translated to clinical care. Traditional drug discovery methods have a >90% failure rate and can take 10-15 years from target identification to clinical use. In contrast, drug repurposing can significantly accelerate translation. We developed a quantitative high-throughput screen to identify efficacious agents against SARS-CoV-2. From a library of 1,425 FDA-approved compounds and clinical candidates, we identified 17 dose-responsive compounds with

Identifiants

DOI: 10.1101/2020.05.27.117184 PMID: 32577649 PMC: PMC7302203
pubmed: 32577649
doi: 10.1101/2020.05.27.117184
pmc: PMC7302203
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL119215
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK089503
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034933
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120623
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002240
Pays : United States
Organisme : NIDCR NIH HHS
ID : T32 DE007057
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI116482
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR000434
Pays : United States

Commentaires et corrections

Type : UpdateIn

Déclaration de conflit d'intérêts

Conflicts of interest The authors declare no conflicts of interest.

Auteurs

Carmen Mirabelli (C)

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

Jesse W Wotring (JW)

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109, USA.

Charles J Zhang (CJ)

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109, USA.

Sean M McCarty (SM)

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109, USA.

Reid Fursmidt (R)

Department of Internal Medicine, Gastroenterology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, 48109, USA.
U-M Center for Drug Repurposing, University of Michigan, Ann Arbor, MI, 48109, USA.

Tristan Frum (T)

Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA.

Namrata S Kadambi (NS)

Department of Internal Medicine, Gastroenterology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, 48109, USA.

Anya T Amin (AT)

Department of Internal Medicine, Gastroenterology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, 48109, USA.

Teresa R O'Meara (TR)

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

Carla D Pretto (CD)

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

Jason R Spence (JR)

Department of Internal Medicine, Gastroenterology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, 48109, USA.
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA.

Jessie Huang (J)

Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA.
The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.

Konstantinos D Alysandratos (KD)

Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA.
The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.

Darrell N Kotton (DN)

Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA.
The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.

Samuel K Handelman (SK)

Department of Internal Medicine, Gastroenterology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, 48109, USA.
U-M Center for Drug Repurposing, University of Michigan, Ann Arbor, MI, 48109, USA.

Christiane E Wobus (CE)

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

Kevin J Weatherwax (KJ)

U-M Center for Drug Repurposing, University of Michigan, Ann Arbor, MI, 48109, USA.
Michigan Institute for Clinical and Health Research (MICHR), University of Michigan, Ann Arbor, MI, 48109, USA.
College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.

George A Mashour (GA)

U-M Center for Drug Repurposing, University of Michigan, Ann Arbor, MI, 48109, USA.
Michigan Institute for Clinical and Health Research (MICHR), University of Michigan, Ann Arbor, MI, 48109, USA.
Department of Anesthesiology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, 48109, USA.

Matthew J O'Meara (MJ)

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.

Jonathan Z Sexton (JZ)

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109, USA.
Department of Internal Medicine, Gastroenterology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, 48109, USA.
U-M Center for Drug Repurposing, University of Michigan, Ann Arbor, MI, 48109, USA.
Michigan Institute for Clinical and Health Research (MICHR), University of Michigan, Ann Arbor, MI, 48109, USA.

Classifications MeSH