Healthy Lifestyle for Prevention of Premature Death Among Users and Nonusers of Common Preventive Medications: A Prospective Study in 2 US Cohorts.
Adult
Aged
Alcohol Drinking
/ adverse effects
Body Mass Index
Cardiovascular Diseases
/ diagnosis
Cause of Death
Cigarette Smoking
/ adverse effects
Diet, Healthy
Exercise
Female
Healthy Lifestyle
Humans
Male
Middle Aged
Mortality, Premature
Prescription Drugs
/ therapeutic use
Primary Prevention
Prognosis
Prospective Studies
Protective Factors
Risk Assessment
Risk Factors
Risk Reduction Behavior
Time Factors
United States
/ epidemiology
lifestyle
mortality
nutrition
preventive medication
primary prevention
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
07 07 2020
07 07 2020
Historique:
pubmed:
25
6
2020
medline:
10
3
2021
entrez:
25
6
2020
Statut:
ppublish
Résumé
Background It remains unknown whether individuals who regularly use preventive medications receive the same benefit from healthy lifestyle as those who do not use medications. We aimed to examine the associations of healthy lifestyle with mortality according to use of major preventive medications, including aspirin, antihypertensives, and lipid-lowering medications. Methods and Results Among 79 043 women in the Nurses' Health Study (1988-2014) and 39 544 men in the Health Professionals Follow-up Study (1986-2014), we defined a healthy lifestyle score based on body mass index, smoking, physical activity, diet, and alcohol intake. We estimated multivariable hazard ratios (HRs) and population-attributable risks of death from any cause, cardiovascular disease, cancer, and other causes in relation to healthy lifestyle according to medication use. We documented 35 195 deaths. A similar association of healthy lifestyle score with lower all-cause mortality was observed among medication users (HR, 0.82 per unit increment; 95% CI, 0.81-0.82) and nonusers (HR, 0.81; 95% CI, 0.79-0.83) (
Identifiants
pubmed: 32578485
doi: 10.1161/JAHA.119.016692
pmc: PMC7670542
doi:
Substances chimiques
Prescription Drugs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e016692Subventions
Organisme : NIDDK NIH HHS
ID : K24 DK098311
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA137178
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA202704
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA167552
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA055075
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA215314
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA215314
Pays : United States
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