Microglia
Aging
Animals
Cytokines
/ cerebrospinal fluid
Female
Gene Expression Regulation
Genetic Variation
Genotype
Glutamic Acid
/ metabolism
Long-Term Potentiation
Macrophages
Male
Membrane Glycoproteins
/ genetics
Microglia
/ physiology
RNA, Messenger
/ genetics
Rats
Receptors, Immunologic
/ genetics
Tumor Necrosis Factor-alpha
/ cerebrospinal fluid
alzheimer
amyloid beta
neuroinflammation
neuroscience
rat
synaptic transmission
tnf-a
trem2
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
24 06 2020
24 06 2020
Historique:
received:
02
04
2020
accepted:
23
06
2020
pubmed:
25
6
2020
medline:
23
2
2021
entrez:
25
6
2020
Statut:
epublish
Résumé
To study the mechanisms by which the p.R47H variant of the microglia gene and Alzheimer's disease (AD) risk factor TREM2 increases dementia risk, we created
Identifiants
pubmed: 32579116
doi: 10.7554/eLife.57513
pii: 57513
pmc: PMC7338048
doi:
pii:
Substances chimiques
Cytokines
0
Membrane Glycoproteins
0
RNA, Messenger
0
Receptors, Immunologic
0
Tumor Necrosis Factor-alpha
0
trem2 protein, rat
0
Glutamic Acid
3KX376GY7L
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01 AG052286
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063407
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG073182
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG064821
Pays : United States
Informations de copyright
© 2020, Ren et al.
Déclaration de conflit d'intérêts
SR, WY, MT, TY, KN, LD No competing interests declared
Références
EMBO J. 2017 Jul 3;36(13):1837-1853
pubmed: 28559417
Cell. 2017 Jun 15;169(7):1276-1290.e17
pubmed: 28602351
Immunity. 2018 May 15;48(5):979-991.e8
pubmed: 29752066
PLoS One. 2011 Apr 27;6(4):e18754
pubmed: 21556148
Neurosci Lett. 1987 Aug 18;79(1-2):195-200
pubmed: 3670729
J Neurosci. 2005 Mar 23;25(12):3219-28
pubmed: 15788779
J Neurosci. 2008 Aug 27;28(35):8668-76
pubmed: 18753367
J Immunol. 2006 Sep 15;177(6):3520-4
pubmed: 16951310
J Biol Chem. 2005 Sep 2;280(35):30768-72
pubmed: 16027166
Exp Neurol. 2005 Jun;193(2):384-93
pubmed: 15869941
N Engl J Med. 2013 Jan 10;368(2):117-27
pubmed: 23150934
Brain Res. 1994 Oct 3;659(1-2):226-30
pubmed: 7820666
Neurology. 2014 Mar 25;82(12):1045-50
pubmed: 24598707
Elife. 2015 Nov 09;4:e09743
pubmed: 26551565
EMBO Mol Med. 2017 Oct;9(10):1356-1365
pubmed: 28855300
Neurobiol Aging. 2011 Aug;32(8):1400-8
pubmed: 19748705
Int J Prev Med. 2013 Jun;4(6):624-30
pubmed: 23930179
Neuron. 2015 Mar 4;85(5):967-81
pubmed: 25741723
Neuron. 2017 Jan 18;93(2):281-290
pubmed: 28103477
Am J Pathol. 1998 Jan;152(1):307-17
pubmed: 9422548
Neuron. 2018 Mar 7;97(5):1023-1031.e7
pubmed: 29518356
Semin Immunol. 2015 Dec;27(6):410-5
pubmed: 27033414
Nature. 2006 Apr 20;440(7087):1054-9
pubmed: 16547515
J Proteome Res. 2012 Aug 3;11(8):4075-90
pubmed: 22731840
EMBO Rep. 2017 Jul;18(7):1186-1198
pubmed: 28483841
Hum Mol Genet. 2018 Jan 15;27(2):211-223
pubmed: 29040522
Sci Rep. 2020 Mar 5;10(1):4122
pubmed: 32139718
Sci Rep. 2019 Mar 19;9(1):4862
pubmed: 30890756
Annu Rev Physiol. 2002;64:355-405
pubmed: 11826273
J Neurochem. 2002 Dec;83(6):1309-20
pubmed: 12472885
J Neurosci. 2010 Nov 17;30(46):15677-85
pubmed: 21084623
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15091-6
pubmed: 23918386
Science. 2002 Mar 22;295(5563):2282-5
pubmed: 11910117
J Neurochem. 2015 Nov;135(3):606-15
pubmed: 26296617
Neuron. 2016 Jul 20;91(2):328-40
pubmed: 27477018
J Neurosci. 2010 Nov 3;30(44):14915-24
pubmed: 21048150
Elife. 2020 Feb 05;9:
pubmed: 32022689
J Biol Chem. 2005 Aug 12;280(32):28912-6
pubmed: 15983050
Aging Cell. 2019 Dec;18(6):e13033
pubmed: 31496118
Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20822-7
pubmed: 21098268
PLoS One. 2014 Sep 23;9(9):e108576
pubmed: 25247712
J Neurosci. 2019 Aug 28;39(35):6992-7005
pubmed: 31235642
J Exp Med. 2018 Mar 5;215(3):745-760
pubmed: 29321225