Relationship and sexual experiences in women with early-onset oestrogen deficiency: Comparison between women with Turner syndrome and premature ovarian insufficiency.
Turner syndrome
oestrogen
premature ovarian insufficiency
puberty
relationship
sexual intercourse
sexual satisfaction
Journal
Clinical endocrinology
ISSN: 1365-2265
Titre abrégé: Clin Endocrinol (Oxf)
Pays: England
ID NLM: 0346653
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
09
04
2020
revised:
01
06
2020
accepted:
18
06
2020
pubmed:
25
6
2020
medline:
19
8
2021
entrez:
25
6
2020
Statut:
ppublish
Résumé
Age at first date and sexual intercourse have been observed to be delayed in women with Turner syndrome (TS), with delayed puberty being the main factor. We sought to assess relationship and sexual experiences comparing women with TS and premature ovarian insufficiency (POI). Cross-sectional observational study. 302 women with TS and 53 women with karyotypically normal POI (median age 33.0 [15.0-78.4] and 26.3 [17.8-52.3], respectively). A self-reporting questionnaire was used to collect data on relationship and sexual experiences. Women with TS were older than women with POI (P = .002). Compared to women with POI, a smaller proportion of women with TS had ever had vaginal sexual intercourse (VSI) (40 [78.4%] vs 169 [58.1%], respectively, P = .006) and women with TS exhibited a delay in the median age at first relationship and VSI (POI 19.3 ± 0.4 vs TS 22.2 ± 1.1, P = <.001). Start of oestrogen replacement therapy at ≤ 14 years of age compared with > 14 years did not result in earlier relationship and sexual debut. After adjusting for age and diagnosis, induction of puberty, as opposed to spontaneous puberty, was associated with a delay in the median age at first relationship and VSI and a reduced probability of having VSI (Hazard ratio = 0.44 [95% confidence interval: 0.32-0.60], P = <.001). Turner syndrome and induction of puberty are associated with a reduced likelihood and a delay in relationship and sexual experiences. Women needing puberty induction and women with TS more than POI have a delayed mean age at first VSI compared to the general population.
Substances chimiques
Estrogens
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
473-481Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
Levin RJ. Sexual activity, health and well-being - the beneficial roles of coitus and masturbation. Sex Relation Ther. 2007;22:135-148.
Witting K, Santtila P, Alanko K, et al. Female sexual function and its associations with number of children, pregnancy, and relationship satisfaction. J Sex Marital Ther. 2008;34:89-106.
Naess EE, Bahr D, Gravholt CH. Health status in women with Turner syndrome: a questionnaire study on health status, education, work participation and aspects of sexual functioning. Clin Endocrinol (Oxf). 2010;72:678-684.
Sheaffer AT, Lange E, Bondy CA. Sexual function in women with Turner syndrome. J Womens Health (Larchmt). 2008;17:27-33.
Ros C, Alobid I, Balasch J, Mullol J, Castelo-Branco C. Turner's syndrome and other forms of congenital hypogonadism impair quality of life and sexual function. Am J Obstet Gynecol. 2013;208(484):e481-e486.
Carel JC, Elie C, Ecosse E, et al. Self-esteem and social adjustment in young women with Turner syndrome-influence of pubertal management and sexuality: population-based cohort study. J Clin Endocrinol Metab. 2006;91:2972-2979.
Schmidt PJ, Cardoso GM, Ross JL, Haq N, Rubinow DR, Bondy CA. Shyness, social anxiety, and impaired self-esteem in Turner syndrome and premature ovarian failure. JAMA. 2006;295:1374-1376.
Yela DA, Soares PM, Benetti-Pinto CL. Influence of sexual function on the social relations and quality of life of women with premature ovarian insufficiency. Rev Bras Ginecol Obstet. 2018;40:66-71.
Lewis R, Tanton C, Mercer CH, et al. Heterosexual practices among young people in britain: evidence from three national surveys of sexual attitudes and lifestyles. J Adolesc Health. 2017;61:694-702.
Wellings K, Jones KG, Mercer CH, et al. The prevalence of unplanned pregnancy and associated factors in Britain: findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3). Lancet. 2013;382:1807-1816.
Mercer CH, Tanton C, Prah P, et al. Changes in sexual attitudes and lifestyles in Britain through the life course and over time: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal). Lancet. 2013;382:1781-1794.
de Sanjose S, Cortes X, Mendez C, et al. Age at sexual initiation and number of sexual partners in the female Spanish population Results from the AFRODITA survey. Eur J Obstet Gynecol Reprod Biol. 2008;140:234-240.
Pavlidis K, McCauley E, Sybert VP. Psychosocial and sexual functioning in women with Turner syndrome. Clin Genet. 1995;47:85-89.
Christopoulos P, Deligeoroglou E, Laggari V, Christogiorgos S, Creatsas G. Psychological and behavioural aspects of patients with Turner syndrome from childhood to adulthood: a review of the clinical literature. J Psychosom Obstet Gynaecol. 2008;29:45-51.
Siegel PT, Clopper R, Stabler B. The psychological consequences of Turner syndrome and review of the National Cooperative Growth Study psychological substudy. Pediatrics. 1998;102:488-491.
McCauley E, Feuillan P, Kushner H, Ross JL. Psychosocial development in adolescents with Turner syndrome. J Dev Behav Pediatr. 2001;22:360-365.
Hutaff-Lee C, Bennett E, Howell S, Tartaglia N. Clinical developmental, neuropsychological, and social-emotional features of Turner syndrome. Am J Med Genet C Semin Med Genet. 2019;181:126-134.
Zhu J, Chan YM. Adult consequences of self-limited delayed puberty. Pediatrics. 2017;139:e20163177.
Lock J. Psychosexual development in adolescents with chronic medical illnesses. Psychosomatics. 1998;39:340-349.
Cameron-Pimblett A, La Rosa C, King TFJ, Davies MC, Conway GS. The Turner syndrome life course project: karyotype-phenotype analyses across the lifespan. Clin Endocrinol (Oxf). 2017;87:532-538.
de Almeida DM, Benetti-Pinto CL, Makuch MY. Sexual function of women with premature ovarian failure. Menopause. 2011;18:262-266.
van der Stege JG, Groen H, van Zadelhoff SJ, et al. Decreased androgen concentrations and diminished general and sexual well-being in women with premature ovarian failure. Menopause. 2008;15:23-31.
Kalantaridou SN, Vanderhoof VH, Calis KA, Corrigan EC, Troendle JF, Nelson LM. Sexual function in young women with spontaneous 46,XX primary ovarian insufficiency. Fertil Steril. 2008;90:1805-1811.
Zuckerman-Levin N, Frolova-Bishara T, Militianu D, Levin M, Aharon-Peretz J, Hochberg Z. Androgen replacement therapy in Turner syndrome: a pilot study. J Clin Endocrinol Metab. 2009;94:4820-4827.
Shifren JL, Braunstein GD, Simon JA, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med. 2000;343:682-688.
Davis SR, van der Mooren MJ, van Lunsen RH, et al. Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Menopause. 2006;13:387-396.
Must A, Phillips SM, Naumova EN, et al. Recall of early menstrual history and menarcheal body size: after 30 years, how well do women remember? Am J Epidemiol. 2002;155:672-679.
Liang W, Chikritzhs T. Errors in recall of age at first sex. PLoS One. 2013;8:e72947.