Ubiquitin-mediated regulation of sterol homeostasis.

Animals Homeostasis Humans Hydroxymethylglutaryl CoA Reductases / genetics Proteolysis Sterols / metabolism Ubiquitin / metabolism Ubiquitin-Protein Ligases / metabolism
Cholesterol E3 ubiquitin ligases ER associated degradation (ERAD) HMG-CoA reductase LDL-cholesterol import RNF145 SCAP SREBP2 Sterol-induced HMGCR degradation Ubiquitin-mediated cholesterol homeostasis gp78

Journal

Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428

Informations de publication

Date de publication:
08 2020
Historique:
received: 11 01 2020
revised: 03 04 2020
accepted: 26 04 2020
pubmed: 25 6 2020
medline: 7 1 2021
entrez: 25 6 2020
Statut: ppublish

Résumé

Cholesterol is an essential component of mammalian membranes, and its homeostasis is strictly regulated, with imbalances causing atherosclerosis, Niemann Pick disease, and familial hypercholesterolemia. Cellular cholesterol supply is mediated by LDL-cholesterol import and de novo cholesterol biosynthesis, and both pathways are adjusted to cellular demand by the cholesterol-sensitive SREBP2 transcription factor. Cholesterol homeostasis is modulated by a wide variety of metabolic pathways and the ubiquitination machinery, in particular E3 ubiquitin ligases. In this article, we review recent progress in understanding the role of E3 ubiquitin ligases in the metabolic control of cellular sterol homeostasis.

Identifiants

DOI: 10.1016/j.ceb.2020.04.010 PMID: 32580085
pubmed: 32580085
pii: S0955-0674(20)30056-9
doi: 10.1016/j.ceb.2020.04.010
pii:
doi:

Substances chimiques

Sterols 0
Ubiquitin 0
Hydroxymethylglutaryl CoA Reductases EC 1.1.1.-
Ubiquitin-Protein Ligases EC 2.3.2.27

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103-111

Subventions

Organisme : Wellcome Trust
ID : 084957/Z/08/Z0
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R001405/1
Pays : United Kingdom

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

Auteurs

Dick J H van den Boomen (DJH)

Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, United Kingdom.

Norbert Volkmar (N)

Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, United Kingdom.

Paul J Lehner (PJ)

Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, United Kingdom. Electronic address: pjl30@cam.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ubiquitin-mediated regulation of sterol homeostasis.
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Ubiquitin-mediated regulation of sterol homeostasis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ubiquitin-mediated regulation of sterol homeostasis.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › 3-Hydroxyacyl-CoA dehydrogenases › Hydroxymethylglutaryl-CoA reductases › Ubiquitin-mediated regulation of sterol homeostasis.
questionsmedicales.fr › Métabolisme › Protéolyse › Ubiquitin-mediated regulation of sterol homeostasis.
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Ubiquitin-mediated regulation of sterol homeostasis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Ubiquitines › Ubiquitine › Ubiquitin-mediated regulation of sterol homeostasis.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › Ubiquitin-mediated regulation of sterol homeostasis.