Specificity, redundancy and dosage thresholds among
Alleles
Animals
GATA4 Transcription Factor
/ genetics
GATA5 Transcription Factor
/ genetics
GATA6 Transcription Factor
/ genetics
Gene Dosage
Gene Expression Regulation, Developmental
Gene Targeting
Genotype
Heart
/ embryology
Morphogenesis
/ genetics
Mutation
Organogenesis
/ genetics
Phenotype
Zebrafish
/ embryology
Embryogenesis
Heart development
Morphogenesis
Progenitor cells
Transcriptional regulation
Journal
Biology open
ISSN: 2046-6390
Titre abrégé: Biol Open
Pays: England
ID NLM: 101578018
Informations de publication
Date de publication:
24 06 2020
24 06 2020
Historique:
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
The Gata4/5/6 sub-family of zinc finger transcription factors regulate many aspects of cardiogenesis. However, critical roles in extra-embryonic endoderm also challenge comprehensive analysis during early mouse cardiogenesis, while zebrafish models have previously relied on knockdown assays. We generated targeted deletions to disrupt each
Identifiants
pubmed: 32580940
pii: 9/6/bio053611
doi: 10.1242/bio.053611
pmc: PMC7327998
pii:
doi:
Substances chimiques
GATA4 Transcription Factor
0
GATA5 Transcription Factor
0
GATA6 Transcription Factor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : R35 HL135778
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD060600
Pays : United States
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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