Sjögren's Syndrome as an Immune-related Adverse Event of Nivolumab Treatment for Gastric Cancer.
Sjögren's syndrome
immune checkpoint inhibitors
immune-related adverse event
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Oct 2020
15 Oct 2020
Historique:
pubmed:
26
6
2020
medline:
23
2
2021
entrez:
26
6
2020
Statut:
ppublish
Résumé
Immune checkpoint inhibitors can affect any organ, including the salivary glands. A case of Sjögren's syndrome (SjS) induced by nivolumab for the treatment of gastric cancer is herein presented. Nivolumab treatment caused marked tumor shrinkage, but xerostomia developed after two cycles. It took 3 months after symptom onset to confirm the diagnosis of SjS. Prednisolone and pilocarpine hydrochloride did not relieve the symptoms. SjS is a relatively rare immune-related adverse event that might sometimes be overlooked. Since SjS can severely impair a patient's quality of life, oncologists should not miss any signs of salivary gland hypofunction and cooperate with specialists for SjS.
Identifiants
pubmed: 32581160
doi: 10.2169/internalmedicine.4701-20
pmc: PMC7662059
doi:
Substances chimiques
Antineoplastic Agents
0
Pilocarpine
01MI4Q9DI3
Nivolumab
31YO63LBSN
Prednisolone
9PHQ9Y1OLM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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