Relationship between FGF21 and drug or nondrug therapy of type 2 diabetes mellitus.
FGF21
T2DM
antidiabetic drugs
diet
exercise
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
03
03
2020
revised:
02
06
2020
accepted:
03
06
2020
pubmed:
26
6
2020
medline:
31
8
2021
entrez:
26
6
2020
Statut:
ppublish
Résumé
Sedentary and high-calorie diets are associated with increased risk of obesity and type 2 diabetes mellitus, while exercise and diet control are also important nondrug treatments for diabetes. Fibroblast growth factor 21 (FGF21) is an important cytokine, which is mainly expressed in liver, fat and muscle tissue responding to nutrition and exercise, and plays an important role in the improvement of glucose and lipid metabolism. Due to the increasing serum FGF21 level in obesity and diabetes, FGF21 can be used as a predictor or biomarker of diabetes. A variety of clinical antidiabetic drugs can reduce the content of FGF21, possibly for the improvement of FGF21 sensitivity. In this paper, we reviewed the interactions between FGF21 and nondrug therapy (diet and exercise) for diabetes and explored the potential value of the combined application of clinical antidiabetic drugs and FGF21.
Substances chimiques
Biomarkers
0
Hypoglycemic Agents
0
fibroblast growth factor 21
0
Fibroblast Growth Factors
62031-54-3
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-67Informations de copyright
© 2020 Wiley Periodicals LLC.
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