Involvement of GPX4 in irisin's protection against ischemia reperfusion-induced acute kidney injury.
Acute Kidney Injury
/ metabolism
Animals
Disease Models, Animal
Down-Regulation
/ physiology
Ferroptosis
/ physiology
Fibronectins
/ metabolism
Inflammation
/ metabolism
Kidney
/ metabolism
Male
Mice
Mice, Inbred C57BL
Mitochondria
/ metabolism
Oxidative Stress
/ physiology
Phospholipid Hydroperoxide Glutathione Peroxidase
/ metabolism
Reactive Oxygen Species
/ metabolism
Reperfusion
/ methods
Reperfusion Injury
/ metabolism
Up-Regulation
/ physiology
AKI
GPX4
ROS
irisin
renal I/R
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
14
01
2020
revised:
21
05
2020
accepted:
13
06
2020
pubmed:
26
6
2020
medline:
9
9
2021
entrez:
26
6
2020
Statut:
ppublish
Résumé
Ischemia reperfusion (I/R)-induced acute kidney injury (AKI) is a common and serious condition. Irisin, an exercise-induced hormone, improves mitochondrial function and reduces reactive oxygen species (ROS) production. Glutathione peroxidase 4 (GPX4) is a key regulator of ferroptosis and its inactivation aggravates renal I/R injury by inducing ROS production. However, the effect of irisin on GPX4 and I/R-induced AKI is still unknown. To study this, male adult mice were subjected to renal I/R by occluding bilateral renal hilum for 30 min, which was followed by 24 hr reperfusion. Our results showed serum irisin levels were decreased in renal I/R mice. Irisin (250 μg/kg) treatment alleviated renal injury, downregulated inflammatory response, improved mitochondrial function, and reduced ER stress and oxidative stress after renal I/R, which were associated with upregulation of GPX4. Treated with RSL3 (a GPX4 inhibitor) abolished irisin's protective effect. Thus, irisin attenuates I/R-induced AKI through upregulating GPX4.
Substances chimiques
FNDC5 protein, mouse
0
Fibronectins
0
Reactive Oxygen Species
0
Phospholipid Hydroperoxide Glutathione Peroxidase
EC 1.11.1.12
glutathione peroxidase 4, mouse
EC 1.11.1.9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
931-945Informations de copyright
© 2020 Wiley Periodicals LLC.
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