Toxicokinetic Studies in Piglets Reveal Age-Related Differences in Systemic Exposure to Zearalenone, Zearalenone-14-Glucoside, and Zearalenone-14-Sulfate.
pig
toxicokinetics
weaning
zearalenone
zearalenone-14-glucoside
zearalenone-14-sulfate
Journal
Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755
Informations de publication
Date de publication:
22 Jul 2020
22 Jul 2020
Historique:
pubmed:
26
6
2020
medline:
20
1
2021
entrez:
26
6
2020
Statut:
ppublish
Résumé
Juveniles are considered as one of the most vulnerable population groups concerning mycotoxins and their modified forms. The weaning stage is a particularly vulnerable period in the life of mammals, reflected in intestinal and immune dysfunction. The current study investigated the toxicokinetic (TK) characteristics of zearalenone (ZEN), zearalenone-14-glucoside (ZEN14G), and zearalenone-14-sulfate (ZEN14S) in weaned (4-week-old) piglets, by means of oral and intravenous administration of equimolar doses, i.e., 331, 500, and 415 μg/kg bodyweight, respectively. Plasma and urine were sampled pre- and post-administration and were quantitatively analyzed for ZEN, ZEN14G, ZEN14S, and
Identifiants
pubmed: 32584032
doi: 10.1021/acs.jafc.0c01943
doi:
Substances chimiques
Glucosides
0
Sulfates
0
zearalenone-14-glucoside
0
Zearalenone
5W827M159J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM