Inactivation of APC Induces CD34 Upregulation to Promote Epithelial-Mesenchymal Transition and Cancer Stem Cell Traits in Pancreatic Cancer.
Adenomatous Polyposis Coli Protein
/ physiology
Animals
Antigens, CD34
/ genetics
Carcinoma, Pancreatic Ductal
/ genetics
Disease Models, Animal
Disease Progression
Epithelial-Mesenchymal Transition
Female
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, SCID
Mutation
Neoplastic Stem Cells
/ metabolism
Pancreatic Neoplasms
/ genetics
Phenotype
Signal Transduction
APC
CD34
cancer stemness
metastasis
pancreatic ductal adenocarcinoma (PDAC)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Jun 2020
23 Jun 2020
Historique:
received:
15
05
2020
revised:
15
06
2020
accepted:
20
06
2020
entrez:
27
6
2020
pubmed:
27
6
2020
medline:
23
3
2021
Statut:
epublish
Résumé
Pancreatic cancer (PC) is a highly lethal malignancy due to the cancer routinely being diagnosed late and having a limited response to chemotherapy. Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic malignant tumor, representing more than 85% of all pancreatic cancers. In the present study, we characterized the phenotypes of concomitant P53 and APC mutations in pancreatic neoplasms driven by the oncogene KRAS in genetically modified mice (GEMM). In this GEMM setting, APC haploinsufficiency coupled with P53 deletion and KRAS
Identifiants
pubmed: 32586050
pii: ijms21124473
doi: 10.3390/ijms21124473
pmc: PMC7352299
pii:
doi:
Substances chimiques
Adenomatous Polyposis Coli Protein
0
Antigens, CD34
0
adenomatous polyposis coli protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
BMC Cancer. 2015 Apr 02;15:217
pubmed: 25881148
Int J Cancer. 1993 Oct 21;55(4):598-603
pubmed: 8406987
Oncogene. 2017 Sep 28;36(39):5532-5543
pubmed: 28581520
Theranostics. 2019 Jan 1;9(2):324-336
pubmed: 30809277
J Natl Cancer Inst. 2013 Nov 20;105(22):1694-700
pubmed: 24203988
EMBO Rep. 2000 Dec;1(6):519-23
pubmed: 11263497
Cancer Res. 1992 Jun 1;52(11):3231-3
pubmed: 1317264
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30
pubmed: 26742998
Nat Rev Cancer. 2001 Oct;1(1):55-67
pubmed: 11900252
Lancet. 2011 Aug 13;378(9791):607-20
pubmed: 21620466
Am J Pathol. 2000 Feb;156(2):433-7
pubmed: 10666372
Annu Rev Pathol. 2008;3:157-88
pubmed: 18039136
Int J Hematol. 1998 Jan;67(1):15-22
pubmed: 9594440
Nat Rev Cancer. 2002 Dec;2(12):897-909
pubmed: 12459728
Cancer J. 2001 Jul-Aug;7(4):266-73
pubmed: 11561603
Science. 1998 Apr 24;280(5363):596-9
pubmed: 9554852
PLoS Genet. 2009 Jul;5(7):e1000547
pubmed: 19578404
Mol Cancer. 2019 May 20;18(1):96
pubmed: 31109321
Nat Rev Gastroenterol Hepatol. 2009 Dec;6(12):699-708
pubmed: 19806144
Ann N Y Acad Sci. 2000 Apr;906:44-50
pubmed: 10818595
Gastroenterology. 2014 Jan;146(1):257-67
pubmed: 24067880
Proc Natl Acad Sci U S A. 1992 May 15;89(10):4452-6
pubmed: 1316610
Bone Marrow Transplant. 2000 Jun;25(12):1249-55
pubmed: 10871729
Cancer Res. 1992 Dec 1;52(23):6696-8
pubmed: 1423316
Oncogene. 2016 Apr 28;35(17):2223-34
pubmed: 26411367
Prostate Cancer Prostatic Dis. 1997 Sep;1(1):32-38
pubmed: 12496931
Nat Rev Gastroenterol Hepatol. 2011 Jan;8(1):27-33
pubmed: 21102532
Blood. 1996 Jul 1;88(1):107-13
pubmed: 8704164
PLoS Genet. 2006 Sep 15;2(9):e146
pubmed: 17002498
Blood. 2001 Jun 15;97(12):3925-30
pubmed: 11389036
Cancer Cell. 2005 Sep;8(3):185-95
pubmed: 16169464
Mol Carcinog. 2012 Jan;51(1):3-13
pubmed: 22162227
Nat Commun. 2014 Mar 18;5:3444
pubmed: 24637522
Ann Oncol. 1999;10 Suppl 4:9-11
pubmed: 10436775
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52
pubmed: 16585505
Gastroenterology. 2012 Feb;142(2):219-32
pubmed: 22155636
Genes Dev. 2006 May 15;20(10):1218-49
pubmed: 16702400
Am J Hematol. 2003 Jul;73(3):149-53
pubmed: 12827650
JAMA. 2001 Aug 22-29;286(8):921-9
pubmed: 11509056
Pancreatology. 2015 Jan-Feb;15(1):8-18
pubmed: 25547205
Nature. 1994 Feb 17;367(6464):645-8
pubmed: 7509044
Blood. 1996 Jan 1;87(1):1-13
pubmed: 8547630
Blood. 1994 Mar 1;83(5):1226-34
pubmed: 7509653
Genes Dev. 2006 Nov 15;20(22):3130-46
pubmed: 17114584
Lancet Oncol. 2016 Jun;17(6):801-810
pubmed: 27160474
Nat Cell Biol. 2001 Apr;3(4):433-8
pubmed: 11283620
Genes Dev. 2003 Dec 15;17(24):3112-26
pubmed: 14681207
Blood. 1996 Jan 15;87(2):535-44
pubmed: 8555475
Stem Cells Dev. 2015 Apr 15;24(8):1008-21
pubmed: 25519836
Hepatology. 1997 Sep;26(3):720-7
pubmed: 9303503
Blood. 1998 Jun 15;91(12):4523-30
pubmed: 9616148