Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study.

Cause of Death Cerebral Palsy / etiology Child, Preschool Chorioamnionitis / diagnosis Cohort Studies Female Fetal Membranes, Premature Rupture Humans Infant, Premature Male Pregnancy Premature Birth Prospective Studies Time Factors
cerebral palsy chorioamnionitis cohort study intrauterine infection preterm birth

Journal

The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410

Informations de publication

Date de publication:
07 2020
Historique:
received: 09 12 2019
revised: 18 02 2020
accepted: 11 03 2020
entrez: 27 6 2020
pubmed: 27 6 2020
medline: 26 11 2020
Statut: ppublish

Résumé

To assess whether chorioamnionitis is associated with cerebral palsy (CP) or death at 2 years' corrected age in infants born before 32 weeks of gestation after spontaneous birth. EPIPAGE-2 is a national, prospective, population-based cohort study of children born preterm in France in 2011; recruitment periods varied by gestational age. This analysis includes infants born alive after preterm labor or preterm premature rupture of membranes from 24 Among 2252 infants born alive spontaneously before 32 weeks of gestation, 116 (5.2%) were exposed to clinical chorioamnionitis. Among 1470 with placental examination data available, 639 (43.5%) had histologic chorioamnionitis. In total, 346 infants died before 2 years and 1586 (83.2% of the survivors) were evaluated for CP at age 2 years. CP rates were 11.1% with and 5.0% without clinical chorioamnionitis (P = .03) and 6.1% with and 5.3% without histologic chorioamnionitis (P = .49). After adjustment for confounding factors, CP risk rose with clinical chorioamnionitis (aOR 2.13, 95% CI 1.12-4.05) but not histologic chorioamnionitis (aOR 1.21, 95% 0.75-1.93). Neither form was associated with the composite outcome "CP or death at age 2." Among infants very preterm born spontaneously, the risk of CP at a corrected age of 2 years was associated with exposure to clinical chorioamnionitis but not histologic chorioamnionitis.

Identifiants

DOI: 10.1016/j.jpeds.2020.03.021 PMID: 32586536
pubmed: 32586536
pii: S0022-3476(20)30349-8
doi: 10.1016/j.jpeds.2020.03.021
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

71-78.e6

Investigateurs

Catherine Arnaud (C)
Chloé Arthuis (C)
Julie Blanc (J)
Pascal Boileau (P)
Thierry Debillon (T)
Claude D'Ercole (C)
Thomas Desplanches (T)
Caroline Diguisto (C)
Aurélie Garbi (A)
Géraldine Gascoin (G)
Catherine Gire (C)
Bruno Langer (B)
Mathilde Letouzey (M)
Isabelle Monier Rm (I)
Andrei Morgan (A)
Jean-Christophe Rozé (JC)
Thomas Schmitz (T)
Barthélémy Tosello (B)
Christophe Vayssiére (C)
Norbert Winer (N)
Jennifer Zeitlin (J)

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Emeline Maisonneuve (E)

Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Statistics Sorbonne Paris Cité, INSERM U1153, Paris, France; Department of Fetal Medicine, Hôpital Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France. Electronic address: emelinem@yahoo.com.

Elsa Lorthe (E)

Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Statistics Sorbonne Paris Cité, INSERM U1153, Paris, France; EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal.

Héloïse Torchin (H)

Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Statistics Sorbonne Paris Cité, INSERM U1153, Paris, France; Paris Descartes University, France; Neonatal Intensive Care Unit, Hôpital Cochin, Paris, France.

Pierre Delorme (P)

Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Statistics Sorbonne Paris Cité, INSERM U1153, Paris, France; Paris Descartes University, France; Department of Obstetrics and Gynecology, Maternité Port-Royal, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, DHU Risques et Grossesse, Paris, France.

Louise Devisme (L)

Department of Pathology, Lille University Hospital CHRU, Lille, France.

Laurence Foix L'Hélias (LF)

Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Statistics Sorbonne Paris Cité, INSERM U1153, Paris, France; Paris Descartes University, France; Neonatal Care Unit, Hôpital Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France.

Stéphane Marret (S)

Neonatal Pediatrics and Intensive Care Unit, Neuropediatrics Department, Centre de référence des troubles des apprentissages de l'enfant, CAMPS, Hôpital Charles Nicolle, Rouen, France; INSERM U1245 - Neovasc team - Perinatal handicap, Institute of Biomedical Research and Innovation, Normandy University, Rouen, France.

Damien Subtil (D)

CHU Lille, Department of Obstetrics and Gynaecology, Jeanne de Flandre Hospital, Lille, France; A 4489, Lille North of France University, Lille, France.

Florence Bodeau-Livinec (F)

Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Statistics Sorbonne Paris Cité, INSERM U1153, Paris, France; Ecole des Hautes Etudes en Santé Publique, Rennes, France.

Véronique Pierrat (V)

Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Statistics Sorbonne Paris Cité, INSERM U1153, Paris, France; CHU Lille, Department of Neonatal Medicine, Jeanne de Flandre Hospital, Lille, France.

Loïc Sentilhes (L)

Department of Obstetrics and Gynecology, Bordeaux University Hospital, Bordeaux, France.

François Goffinet (F)

Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Statistics Sorbonne Paris Cité, INSERM U1153, Paris, France; Paris Descartes University, France; Department of Obstetrics and Gynecology, Maternité Port-Royal, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, DHU Risques et Grossesse, Paris, France.

Pierre-Yves Ancel (PY)

Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Statistics Sorbonne Paris Cité, INSERM U1153, Paris, France; Paris Descartes University, France; Clinical Research Unit, Center for Clinical Investigation P1419, Cochin Broca Hôtel-Dieu Hospital, Paris, France.

Gilles Kayem (G)

Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Statistics Sorbonne Paris Cité, INSERM U1153, Paris, France; Paris Descartes University, France; Department of Obstetrics and Gynecology, Hôpital Armand Trousseau, Sorbonne University, Assistance Publique-Hôpitaux de Paris, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Cause de décès › Association of Chorioamnionitis with Cerebral...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Paralysie cérébrale › Association of Chorioamnionitis with Cerebral...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Association of Chorioamnionitis with Cerebral...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies foetales › Chorioamnionite › Association of Chorioamnionitis with Cerebral...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Association of Chorioamnionitis with Cerebral...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Complications du travail obstétrical › Rupture prématurée des membranes foetales › Association of Chorioamnionitis with Cerebral...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of Chorioamnionitis with Cerebral...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Prématuré › Association of Chorioamnionitis with Cerebral...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Association of Chorioamnionitis with Cerebral...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Complications du travail obstétrical › Travail obstétrical prématuré › Naissance prématurée › Association of Chorioamnionitis with Cerebral...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Association of Chorioamnionitis with Cerebral...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Association of Chorioamnionitis with Cerebral...