Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid.

Acyclovir / therapeutic use Antiviral Agents / therapeutic use Betacoronavirus / genetics Brain / diagnostic imaging COVID-19 Coronavirus Infections / cerebrospinal fluid Female Glial Fibrillary Acidic Protein / cerebrospinal fluid Humans Immunoglobulins, Intravenous / therapeutic use Immunologic Factors / therapeutic use Interleukin-6 / cerebrospinal fluid Leukoencephalitis, Acute Hemorrhagic / cerebrospinal fluid Magnetic Resonance Imaging Middle Aged Neurofilament Proteins / cerebrospinal fluid Pandemics Plasma Exchange Pneumonia, Viral / cerebrospinal fluid RNA, Viral / cerebrospinal fluid Real-Time Polymerase Chain Reaction SARS-CoV-2 Tomography, X-Ray Computed Viral Tropism tau Proteins / cerebrospinal fluid

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
08 09 2020
Historique:
received: 14 05 2020
accepted: 19 06 2020
pubmed: 27 6 2020
medline: 18 9 2020
entrez: 27 6 2020
Statut: ppublish

Résumé

Here, we report a case of COVID-19-related acute necrotizing encephalopathy where SARS-CoV-2 RNA was found in CSF 19 days after symptom onset after testing negative twice. Although monocytes and protein levels in CSF were only marginally increased, and our patient never experienced a hyperinflammatory state, her neurologic function deteriorated into coma. MRI of the brain showed pathologic signal symmetrically in central thalami, subinsular regions, medial temporal lobes, and brain stem. Extremely high concentrations of the neuronal injury markers neurofilament light and tau, as well as an astrocytic activation marker, glial fibrillary acidic protein, were measured in CSF. Neuronal rescue proteins and other pathways were elevated in the in-depth proteomics analysis. The patient received IV immunoglobulins and plasma exchange. Her neurologic status improved, and she was extubated 4 weeks after symptom onset. This case report highlights the neurotropism of SARS-CoV-2 in selected patients and emphasizes the importance of repeated lumbar punctures and CSF analyses in patients with suspected COVID-19 and neurologic symptoms.

Identifiants

DOI: 10.1212/WNL.0000000000010250 PMID: 32586897 PMC: PMC7538220
pubmed: 32586897
pii: WNL.0000000000010250
doi: 10.1212/WNL.0000000000010250
pmc: PMC7538220
doi:

Substances chimiques

Antiviral Agents 0
Glial Fibrillary Acidic Protein 0
Immunoglobulins, Intravenous 0
Immunologic Factors 0
Interleukin-6 0
Neurofilament Proteins 0
RNA, Viral 0
neurofilament protein L 0
tau Proteins 0
Acyclovir X4HES1O11F

Types de publication

Case Reports Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

445-449

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

Références

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pubmed: 32228363
Virology. 1992 May;188(1):274-84
pubmed: 1314455
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pubmed: 2543129
Int J Infect Dis. 2020 May;94:55-58
pubmed: 32251791
J Med Virol. 2020 Jul;92(7):699-702
pubmed: 32314810
Brain Dev. 1997 Mar;19(2):81-92
pubmed: 9105653

Auteurs

Johan Virhammar (J)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Eva Kumlien (E)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

David Fällmar (D)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.
ORCID: 0000-0001-5615-2036

Robert Frithiof (R)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Sven Jackmann (S)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Mattias K Sköld (MK)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Mohamed Kadir (M)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Jens Frick (J)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Jonas Lindeberg (J)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Henrik Olivero-Reinius (H)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Mats Ryttlefors (M)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Janet L Cunningham (JL)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Johan Wikström (J)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Anna Grabowska (A)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Kåre Bondeson (K)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Jonas Bergquist (J)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Henrik Zetterberg (H)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden.

Elham Rostami (E)

From the Department of Neuroscience (J.V., E.K., S.J.), Neurology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (D.F., J.W., A.G.), Radiology, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences (R.F., H.D.P.D.O.-R.), Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Neuroscience (M.K.S., H.D.P.D.O.-R., E.R.), Neurosurgery, Uppsala University, Uppsala, Sweden; Department of Internal Medicine (M.K., J.L.), Nyköping Hospital, Nyköping, Sweden; Department of Radiology (J.F.), Nyköping Hospital, Nyköping, Sweden; Department of Neuroscience (J.L.C.), Psychiatry, Uppsala University, Uppsala, Sweden; Department of Medical Sciences (K.B.), Uppsala University, Uppsala, Sweden; Department of Chemistry-BMC (J.B.), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal; and Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden. Elham.rostami@neuro.uu.se.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Hypoxanthines › Guanine › Aciclovir › Acute necrotizing encephalopathy with...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Acute necrotizing encephalopathy with...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Acute necrotizing encephalopathy with...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Acute necrotizing encephalopathy with...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Acute necrotizing encephalopathy with...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Nidovirales › Infections à Coronaviridae › Infections à coronavirus › Acute necrotizing encephalopathy with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines de filaments intermédiaires › Protéine gliofibrillaire acide › Acute necrotizing encephalopathy with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Acute necrotizing encephalopathy with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Immunoglobulines par voie veineuse › Acute necrotizing encephalopathy with...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Acute necrotizing encephalopathy with...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Acute necrotizing encephalopathy with...
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