Elevated V-ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer.

Animals Breast Neoplasms / genetics Cell Line, Tumor Disease Models, Animal Female Humans Mice Oncogenes / genetics PTEN Phosphohydrolase / metabolism Signal Transduction Transfection

Journal

Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042

Informations de publication

Date de publication:
10 2020
Historique:
received: 26 01 2020
revised: 30 04 2020
accepted: 18 06 2020
pubmed: 27 6 2020
medline: 1 9 2021
entrez: 27 6 2020
Statut: ppublish

Résumé

PTEN loss-of-function contributes to hyperactivation of the PI3K pathway and to drug resistance in breast cancer. Unchecked PI3K pathway signaling increases activation of the mechanistic target of rapamycin complex 1 (mTORC1), which promotes tumorigenicity. Several studies have suggested that vacuolar (H

Identifiants

DOI: 10.1158/1541-7786.MCR-20-0088 PMID: 32587106
pubmed: 32587106
pii: 1541-7786.MCR-20-0088
doi: 10.1158/1541-7786.MCR-20-0088
doi:

Substances chimiques

PTEN Phosphohydrolase EC 3.1.3.67
PTEN protein, human EC 3.1.3.67

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1477-1490

Subventions

Organisme : CIHR
Pays : Canada

Informations de copyright

©2020 American Association for Cancer Research.

Auteurs

Amro H Mohammad (AH)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

Sung-Hoon Kim (SH)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0002-3825-5653

Nicholas Bertos (N)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Molecular Oncology Group, McGill University Health Centre, Montreal, Quebec, Canada.
ORCID: 0000-0001-5466-6076

Wissal El-Assaad (W)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

Ipshita Nandi (I)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

Harvey Smith (H)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.

Jieyi Yang (J)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

Owen J Chen (OJ)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0003-1443-9746

Isabelle Gamache (I)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.

Trisha Rao (T)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

Bruno Gagnon (B)

Department of Family Medicine and Emergency Medicine, Laval University, Laval, Quebec, Canada.
ORCID: 0000-0003-0843-0366

Tina Gruosso (T)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Molecular Oncology Group, McGill University Health Centre, Montreal, Quebec, Canada.

Michel L Tremblay (ML)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0002-0281-541X

Nahum Sonenberg (N)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0002-4707-8759

Marie-Christine Guiot (MC)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
McGill University Health Centre, McGill University, Montreal, Quebec, Canada.

William Muller (W)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

Morag Park (M)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
Molecular Oncology Group, McGill University Health Centre, Montreal, Quebec, Canada.
McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
Department of Oncology, McGill University, Montreal, Quebec, Canada.

Jose G Teodoro (JG)

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada. jose.teodoro@mcgill.ca.
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0002-3713-6839

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Elevated V-ATPase Activity Following PTEN Loss...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Elevated V-ATPase Activity Following PTEN Loss...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Elevated V-ATPase Activity Following PTEN Loss...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Elevated V-ATPase Activity Following PTEN Loss...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Elevated V-ATPase Activity Following PTEN Loss...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Elevated V-ATPase Activity Following PTEN Loss...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › Elevated V-ATPase Activity Following PTEN Loss...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Phosphohydrolase PTEN › Elevated V-ATPase Activity Following PTEN Loss...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Elevated V-ATPase Activity Following PTEN Loss...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Transfection › Elevated V-ATPase Activity Following PTEN Loss...