Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer's disease mouse model.

Alzheimer Disease / diagnostic imaging Animals Disease Models, Animal Fluorine Radioisotopes / metabolism Hippocampus / diagnostic imaging Magnetic Resonance Imaging / methods Mice Mice, Inbred C57BL Plaque, Amyloid / diagnostic imaging Positron-Emission Tomography / methods Radiopharmaceuticals / metabolism Thalamus / diagnostic imaging

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
25 06 2020
Historique:
received: 09 12 2019
accepted: 07 04 2020
entrez: 27 6 2020
pubmed: 27 6 2020
medline: 15 12 2020
Statut: epublish

Résumé

The emergence of PET probes for amyloid plaques and neurofibrillary tangles, hallmarks of Alzheimer disease (AD), enables monitoring of pathology in AD mouse models. However, small-animal PET imaging is limited by coarse spatial resolution. We have installed a custom-fabricated PET insert into our small-animal MRI instrument and used PET/MRI hybrid imaging to define regions of amyloid vulnerability in 5xFAD mice. We compared fluorine-18 [

Identifiants

DOI: 10.1038/s41598-020-67284-z PMID: 32587315 PMC: PMC7316864
pubmed: 32587315
doi: 10.1038/s41598-020-67284-z
pii: 10.1038/s41598-020-67284-z
pmc: PMC7316864
doi:

Substances chimiques

Fluorine Radioisotopes 0
Radiopharmaceuticals 0
Fluorine-18 GZ5I74KB8G

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

10379

Subventions

Organisme : NIA NIH HHS
ID : R01 AG026660
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS096275
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061350
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057593
Pays : United States
Organisme : NCI NIH HHS
ID : RC2 CA148971
Pays : United States

Commentaires et corrections

Type : ErratumIn

Références

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Auteurs

Georgia R Frost (GR)

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Program of Neuroscience, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, 10021, USA.

Valerie Longo (V)

Small Animal Imaging Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Thomas Li (T)

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Program of Neuroscience, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, 10021, USA.

Lauren A Jonas (LA)

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Program of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, 10021, USA.

Martin Judenhofer (M)

Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.

Simon Cherry (S)

Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.

Jason Koutcher (J)

Departments of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Departments of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Carl Lekaye (C)

Departments of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Pat Zanzonico (P)

Departments of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. zanzonip@mskcc.org.

Yue-Ming Li (YM)

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. liy2@mskcc.org.
Program of Neuroscience, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, 10021, USA. liy2@mskcc.org.
Program of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, 10021, USA. liy2@mskcc.org.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Hybrid PET/MRI enables high-spatial...
questionsmedicales.fr › Eucaryotes › Animaux › Hybrid PET/MRI enables high-spatial...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Hybrid PET/MRI enables high-spatial...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du fluor › Hybrid PET/MRI enables high-spatial...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Hybrid PET/MRI enables high-spatial...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Hybrid PET/MRI enables high-spatial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hybrid PET/MRI enables high-spatial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Hybrid PET/MRI enables high-spatial...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque amyloïde › Hybrid PET/MRI enables high-spatial...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Hybrid PET/MRI enables high-spatial...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Hybrid PET/MRI enables high-spatial...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Thalamus › Hybrid PET/MRI enables high-spatial...