Synthesis and Evaluation of a Macrocyclic Actinium-225 Chelator, Quality Control and In Vivo Evaluation of

actinium-225 melanocortin 1 receptor melanoma peptide radionuclide therapy targeted alpha therapy

Journal

Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783

Informations de publication

Date de publication:
04 Sep 2020
Historique:
received: 23 06 2020
pubmed: 27 6 2020
medline: 2 3 2021
entrez: 27 6 2020
Statut: ppublish

Résumé

Targeted alpha-therapy (TAT) has great potential for treating a broad range of late-stage cancers by delivering a focused and lethal radiation dose to tumors. Actinium-225 (

Identifiants

pubmed: 32588455
doi: 10.1002/chem.202002999
doi:

Substances chimiques

Actinium-225 0
Chelating Agents 0
Coordination Complexes 0
Crown Compounds 0
alpha-MSH 581-05-5
Actinium NIK1K0956U

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11435-11440

Subventions

Organisme : Natural Sciences and Engineering Research Council of Canada
ID : RGPIN 2016-04413

Informations de copyright

© 2020 Wiley-VCH GmbH.

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Auteurs

Hua Yang (H)

Life Sciences Division, TRIUMF, Vancouver, BC, V6T 2A3, Canada.

Chengcheng Zhang (C)

BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.

Zheliang Yuan (Z)

Life Sciences Division, TRIUMF, Vancouver, BC, V6T 2A3, Canada.
Key Laboratory of the Ministry of Education for, Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, Jinhua, 321004, P.R. China.

Cristina Rodriguez-Rodriguez (C)

Faculty of Pharmaceutical Sciences, Department of Physics and Astronomy and Centre for Comparative, Medicine, University of British Columbia, Vancouver, BC, V6T 1W5, Canada.

Andrew Robertson (A)

Life Sciences Division, TRIUMF, Vancouver, BC, V6T 2A3, Canada.

Valery Radchenko (V)

Life Sciences Division, TRIUMF, Vancouver, BC, V6T 2A3, Canada.
Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada.

Randy Perron (R)

Canadian Nuclear Laboratories, Chalk River, ON, K0J 1J0, Canada.

Denise Gendron (D)

Canadian Nuclear Laboratories, Chalk River, ON, K0J 1J0, Canada.

Patrick Causey (P)

Canadian Nuclear Laboratories, Chalk River, ON, K0J 1J0, Canada.

Feng Gao (F)

Life Sciences Division, TRIUMF, Vancouver, BC, V6T 2A3, Canada.

François Bénard (F)

BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
Department of Radiology, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.

Paul Schaffer (P)

Life Sciences Division, TRIUMF, Vancouver, BC, V6T 2A3, Canada.
Department of Radiology, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.
Department of Chemistry, Simon Fraser University, Burnaby, V5A 1S6, Canada.

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Classifications MeSH