Understanding the Interaction of Polyelectrolyte Architectures with Proteins and Biosystems.
complementary binding
counterion release
heparin
inflammation
polyelectrolytes
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
19 02 2021
19 02 2021
Historique:
received:
04
05
2020
pubmed:
27
6
2020
medline:
19
3
2021
entrez:
27
6
2020
Statut:
ppublish
Résumé
The counterions neutralizing the charges on polyelectrolytes such as DNA or heparin may dissociate in water and greatly influence the interaction of such polyelectrolytes with biomolecules, particularly proteins. In this Review we give an overview of studies on the interaction of proteins with polyelectrolytes and how this knowledge can be used for medical applications. Counterion release was identified as the main driving force for the binding of proteins to polyelectrolytes: Patches of positive charge become multivalent counterions of the polyelectrolyte and lead to the release of counterions from the polyelectrolyte and a concomitant increase in entropy. This is shown from investigations on the interaction of proteins with natural and synthetic polyelectrolytes. Special emphasis is paid to sulfated dendritic polyglycerols (dPGS). The Review demonstrates that we are moving to a better understanding of charge-charge interactions in systems of biological relevance. Research along these lines will aid and promote the design of synthetic polyelectrolytes for medical applications.
Identifiants
pubmed: 32589355
doi: 10.1002/anie.202006457
pmc: PMC7894192
doi:
Substances chimiques
Antineoplastic Agents
0
Drug Carriers
0
Glycosaminoglycans
0
Polyelectrolytes
0
Proteins
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3882-3904Subventions
Organisme : CIHR
ID : MOP-119425
Pays : Canada
Informations de copyright
© 2020 The Authors. Published by Wiley-VCH GmbH.
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