Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
25 06 2020
25 06 2020
Historique:
received:
05
03
2020
revised:
19
05
2020
accepted:
01
06
2020
entrez:
27
6
2020
pubmed:
27
6
2020
medline:
22
1
2021
Statut:
ppublish
Résumé
Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
Identifiants
pubmed: 32589957
pii: S0092-8674(20)30691-7
doi: 10.1016/j.cell.2020.06.004
pmc: PMC8800485
mid: NIHMS1607575
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1464-1474Subventions
Organisme : NIA NIH HHS
ID : U01 AG055135
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR071158
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG055137
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR071130
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR071133
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK112340
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK036836
Pays : United States
Organisme : NIBIB NIH HHS
ID : U24 EB023674
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK112341
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK112326
Pays : United States
Organisme : NIH HHS
ID : U24 OD026629
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK112342
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK112331
Pays : United States
Organisme : NIAMS NIH HHS
ID : U24 AR071113
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR071160
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK112348
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG055133
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK072476
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR071128
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR071124
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM070335
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK112349
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR071150
Pays : United States
Investigateurs
Joshua N Adkins
(JN)
David Amar
(D)
Surendra Dasari
(S)
Jonelle K Drugan
(JK)
Charles R Evans
(CR)
Facundo M Fernandez
(FM)
Yafeng Li
(Y)
Malene E Lindholm
(ME)
Christopher D Nogiec
(CD)
Shlomit Radom-Aizik
(S)
James A Sanford
(JA)
Simon Schenk
(S)
Michael P Snyder
(MP)
Lyl Tomlinson
(L)
Russell P Tracy
(RP)
Scott Trappe
(S)
Patrick Vanderboom
(P)
Martin J Walsh
(MJ)
D Lee Alekel
(D)
Iddil Bekirov
(I)
Amanda T Boyce
(AT)
Josephine Boyington
(J)
Jerome L Fleg
(JL)
Lyndon J O Joseph
(LJO)
Maren R Laughlin
(MR)
Padma Maruvada
(P)
Stephanie A Morris
(SA)
Joan A McGowan
(JA)
Concepcion Nierras
(C)
Vinay Pai
(V)
Charlotte Peterson
(C)
Ed Ramos
(E)
Mary C Roary
(MC)
John P Williams
(JP)
Ashley Xia
(A)
Elaine Cornell
(E)
Jessica Rooney
(J)
Michael E Miller
(ME)
Walter T Ambrosius
(WT)
Scott Rushing
(S)
Cynthia L Stowe
(CL)
W Jack Rejeski
(W)
Barbara J Nicklas
(BJ)
Marco Pahor
(M)
Ching-Ju Lu
(CJ)
Todd Trappe
(T)
Toby Chambers
(T)
Ulrika Raue
(U)
Bridget Lester
(B)
Bryan C Bergman
(BC)
David H Bessesen
(DH)
Catherine M Jankowski
(CM)
Wendy M Kohrt
(WM)
Edward L Melanson
(EL)
Kerrie L Moreau
(KL)
Irene E Schauer
(IE)
Robert S Schwartz
(RS)
William E Kraus
(WE)
Cris A Slentz
(CA)
Kim M Huffman
(KM)
Johanna L Johnson
(JL)
Leslie H Willis
(LH)
Leslie Kelly
(L)
Joseph A Houmard
(JA)
Gabriel Dubis
(G)
Nick Broskey
(N)
Bret H Goodpaster
(BH)
Lauren M Sparks
(LM)
Paul M Coen
(PM)
Dan M Cooper
(DM)
Fadia Haddad
(F)
Tuomo Rankinen
(T)
Eric Ravussin
(E)
Neil Johannsen
(N)
Melissa Harris
(M)
John M Jakicic
(JM)
Anne B Newman
(AB)
Daniel D Forman
(DD)
Erin Kershaw
(E)
Renee J Rogers
(RJ)
Bradley C Nindl
(BC)
Lindsay C Page
(LC)
Maja Stefanovic-Racic
(M)
Susan L Barr
(SL)
Blake B Rasmussen
(BB)
Tatiana Moro
(T)
Doug Paddon-Jones
(D)
Elena Volpi
(E)
Heidi Spratt
(H)
Nicolas Musi
(N)
Sara Espinoza
(S)
Darpan Patel
(D)
Monica Serra
(M)
Jonathan Gelfond
(J)
Aisling Burns
(A)
Marcas M Bamman
(MM)
Thomas W Buford
(TW)
Gary R Cutter
(GR)
Sue C Bodine
(SC)
Karyn Esser
(K)
Rodger P Farrar
(RP)
Laurie J Goodyear
(LJ)
Michael F Hirshman
(MF)
Brent G Albertson
(BG)
Wei-Jun Qian
(WJ)
Paul Piehowski
(P)
Marina A Gritsenko
(MA)
Matthew E Monore
(ME)
Vladislav A Petyuk
(VA)
Jason E McDermott
(JE)
Joshua N Hansen
(JN)
Chelsea Hutchison
(C)
Samuel Moore
(S)
David A Gaul
(DA)
Clary B Clish
(CB)
Julian Avila-Pacheco
(J)
Courtney Dennis
(C)
Manolis Kellis
(M)
Steve Carr
(S)
Pierre M Jean-Beltran
(PM)
Hasmik Keshishian
(H)
D R Mani
(DR)
Karl Clauser
(K)
Karsten Krug
(K)
Charlie Mundorff
(C)
Cadence Pearce
(C)
Anna A Ivanova
(AA)
Eric A Ortlund
(EA)
Kristal Maner-Smith
(K)
Karan Uppal
(K)
Tiantian Zhang
(T)
Stuart C Sealfon
(SC)
Elena Zaslavsky
(E)
Venugopalan Nair
(V)
SiDe Li
(S)
Nimisha Jain
(N)
YongChao Ge
(Y)
Yifei Sun
(Y)
German Nudelman
(G)
Frederique Ruf-Zamojski
(F)
Gregory Smith
(G)
Nhanna Pincas
(N)
Aliza Rubenstein
(A)
Mary Anne Amper
(M)
Nitish Seenarine
(N)
Tuuli Lappalainen
(T)
Ian R Lanza
(IR)
K Sreekumaran Nair
(K)
Katherine Klaus
(K)
Stephen B Montgomery
(SB)
Kevin S Smith
(KS)
Nicole R Gay
(NR)
Bingqing Zhao
(B)
Chia-Jiu Hung
(CJ)
Navid Zebarjadi
(N)
Brunilda Balliu
(B)
Laure Fresard
(L)
Charles F Burant
(CF)
Jun Z Li
(JZ)
Maureen Kachman
(M)
Tanu Soni
(T)
Alexander B Raskind
(AB)
Robert Gerszten
(R)
Jeremy Robbins
(J)
Olga Ilkayeva
(O)
Michael J Muehlbauer
(MJ)
Christopher B Newgard
(CB)
Euan A Ashley
(EA)
Matthew T Wheeler
(MT)
David Jimenez-Morales
(D)
Archana Raja
(A)
Karen P Dalton
(KP)
Jimmy Zhen
(J)
Young Suk Kim
(Y)
Jeffrey W Christle
(JW)
Shruti Marwaha
(S)
Elizabeth T Chin
(ET)
Steven G Hershman
(SG)
Trevor Hastie
(T)
Robert Tibshirani
(R)
Manuel A Rivas
(MA)
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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