Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent Patient.
Journal
Clinical neuropharmacology
ISSN: 1537-162X
Titre abrégé: Clin Neuropharmacol
Pays: United States
ID NLM: 7607910
Informations de publication
Date de publication:
Historique:
pubmed:
27
6
2020
medline:
10
4
2021
entrez:
27
6
2020
Statut:
ppublish
Résumé
Cataplexy is a clinical entity that is characterized by transient muscle tone loss that mostly occurring as a part of narcolepsy. On the other hand, isolated cataplexy (IC) (hereditary cataplexy) is defined as loss of muscle tone that is not accompanied by narcolepsy. Emotional reactions may trigger IC episodes. Additionally, human leukocyte antigen (HLA) DQB1 alleles were shown to be related to IC. Various antidepressants are useful in the treatment of IC; however, there is limited knowledge on the use of antipsychotics in the treatment of IC. A 16-year-old adolescent girl was consulted child and adolescent psychiatry outpatient clinic with complaint of sudden episodes of loss of muscle tone. Her HLA typing showed HLA DQB1*03 haplotype. She was diagnosed with IC and was prescribed aripiprazole 2.5 mg/d and her IC symptoms disappeared and never recurred over 6 months of follow-up. In this case report, we present an adolescent girl with IC that is successfully treated with aripiprazole, an antipsychotic. This case report suggests that aripiprazole may be safely used in some adolescents who diagnosed with IC.
Sections du résumé
BACKGROUND
BACKGROUND
Cataplexy is a clinical entity that is characterized by transient muscle tone loss that mostly occurring as a part of narcolepsy. On the other hand, isolated cataplexy (IC) (hereditary cataplexy) is defined as loss of muscle tone that is not accompanied by narcolepsy. Emotional reactions may trigger IC episodes. Additionally, human leukocyte antigen (HLA) DQB1 alleles were shown to be related to IC. Various antidepressants are useful in the treatment of IC; however, there is limited knowledge on the use of antipsychotics in the treatment of IC.
CASE REPORT
METHODS
A 16-year-old adolescent girl was consulted child and adolescent psychiatry outpatient clinic with complaint of sudden episodes of loss of muscle tone. Her HLA typing showed HLA DQB1*03 haplotype. She was diagnosed with IC and was prescribed aripiprazole 2.5 mg/d and her IC symptoms disappeared and never recurred over 6 months of follow-up.
CONCLUSIONS
CONCLUSIONS
In this case report, we present an adolescent girl with IC that is successfully treated with aripiprazole, an antipsychotic. This case report suggests that aripiprazole may be safely used in some adolescents who diagnosed with IC.
Identifiants
pubmed: 32590615
doi: 10.1097/WNF.0000000000000398
doi:
Substances chimiques
Antipsychotic Agents
0
Aripiprazole
82VFR53I78
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM