CTL Clonotypes with Higher TCR Affinity Have Better Ability to Reduce the HIV Latent Reservoir.

CD4-Positive T-Lymphocytes / immunology HIV Infections / immunology HIV-1 / physiology Humans Interferon-gamma / immunology Receptors, Antigen, T-Cell / immunology Virus Latency / immunology

Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
01 08 2020
Historique:
received: 16 07 2019
accepted: 23 05 2020
pubmed: 28 6 2020
medline: 16 3 2021
entrez: 28 6 2020
Statut: ppublish

Résumé

The success of the shock and kill strategy for the HIV cure depends both on the reactivation of the latent reservoir and on the ability of the immune system to eliminate infected cells. As latency reversal alone has not shown any impact in the size of the latent reservoir, ensuring that effector CTLs are able to recognize and kill HIV-infected cells could contribute to reservoir reduction. In this study, we investigated which functional aspects of human CTLs are associated with a better capacity to kill HIV-infected CD4

Identifiants

DOI: 10.4049/jimmunol.1900811 PMID: 32591402
pubmed: 32591402
pii: jimmunol.1900811
doi: 10.4049/jimmunol.1900811
doi:

Substances chimiques

IFNG protein, human 0
Receptors, Antigen, T-Cell 0
Interferon-gamma 82115-62-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

699-707

Informations de copyright

Copyright © 2020 by The American Association of Immunologists, Inc.

Auteurs

Noemia S Lima (NS)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814.
ORCID: 0000-0003-4399-487X

Hiroshi Takata (H)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.
ORCID: 0000-0003-1457-6919

Szu-Han Huang (SH)

Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY 10021.
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037.
ORCID: 0000-0003-1420-3186

Alexander Haregot (A)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.

Julie Mitchell (J)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.
ORCID: 0000-0001-7400-7027

Stephen Blackmore (S)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.

Ayanna Garland (A)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.

Aaron Sy (A)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.

Pearline Cartwright (P)

Vaccine and Gene Therapy Institute-Florida, Port St. Lucie, FL 34987.

Jean-Pierre Routy (JP)

Division of Hematology and Chronic Viral Illness Service, McGill University, Montreal, Quebec H3A 0G4, Canada.
ORCID: 0000-0001-9897-7589

Nelson L Michael (NL)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
ORCID: 0000-0001-5882-5548

Victor Appay (V)

Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Université, INSERM, Paris 75005, France; and.
International Research Center of Medical Sciences, Kumamoto University, Kumamoto 860-8555, Japan.

R Brad Jones (RB)

Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY 10021.
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037.

Lydie Trautmann (L)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910; trautmly@ohsu.edu.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.
ORCID: 0000-0002-3012-0009

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › CTL Clonotypes with Higher TCR Affinity Have...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › CTL Clonotypes with Higher TCR Affinity Have...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › CTL Clonotypes with Higher TCR Affinity Have...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CTL Clonotypes with Higher TCR Affinity Have...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › CTL Clonotypes with Higher TCR Affinity Have...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › CTL Clonotypes with Higher TCR Affinity Have...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Latence virale › CTL Clonotypes with Higher TCR Affinity Have...