Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome.
Aged
Betacoronavirus
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
COVID-19
Cells, Cultured
Coronavirus Infections
/ blood
Cytokines
/ metabolism
Female
Humans
Immunologic Memory
Kinetics
Longitudinal Studies
Male
Middle Aged
Pandemics
Phenotype
Pneumonia, Viral
/ blood
Respiratory Distress Syndrome
/ blood
SARS-CoV-2
Severity of Illness Index
Spike Glycoprotein, Coronavirus
/ immunology
Viral Load
/ immunology
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
26 06 2020
26 06 2020
Historique:
received:
08
06
2020
accepted:
23
06
2020
entrez:
28
6
2020
pubmed:
28
6
2020
medline:
16
7
2020
Statut:
ppublish
Résumé
SARS-CoV-2 has been identified as the causative agent of a global outbreak of respiratory tract disease (COVID-19). In some patients the infection results in moderate to severe acute respiratory distress syndrome (ARDS), requiring invasive mechanical ventilation. High serum levels of IL-6, IL-10 and an immune hyperresponsiveness referred to as a 'cytokine storm' have been associated with poor clinical outcome. Despite the large numbers of COVID-19 cases and deaths, information on the phenotype and kinetics of SARS-CoV-2-specific T cells is limited. Here, we studied 10 COVID-19 patients who required admission to an intensive care unit and detected SARS-CoV-2-specific CD4
Identifiants
pubmed: 32591408
pii: 5/48/eabd2071
doi: 10.1126/sciimmunol.abd2071
pmc: PMC7319493
pii:
doi:
Substances chimiques
Cytokines
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020, American Association for the Advancement of Science.
Références
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
Curr Protoc Immunol. 2016 Aug 01;114:18.19.1-18.19.24
pubmed: 27479659
Sci Immunol. 2017 Aug 4;2(14):
pubmed: 28778905
J Immunol Methods. 2015 Jul;422:28-34
pubmed: 25862607
J Immunol. 2008 Oct 15;181(8):5490-500
pubmed: 18832706
Science. 2020 May 22;368(6493):860-868
pubmed: 32291278
J Allergy Clin Immunol. 2020 Jul;146(1):128-136.e4
pubmed: 32425269
Eur J Immunol. 2013 Nov;43(11):2797-809
pubmed: 24258910
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Emerg Infect Dis. 2020 Jul;26(7):1478-1488
pubmed: 32267220
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Nucleic Acids Res. 2019 Jul 2;47(W1):W502-W506
pubmed: 31114900
Lancet. 2020 Feb 15;395(10223):514-523
pubmed: 31986261
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992387
Nat Med. 2020 Apr;26(4):453-455
pubmed: 32284614
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Nature. 1999 Oct 14;401(6754):708-12
pubmed: 10537110
J Med Virol. 2021 Jan;93(1):375-382
pubmed: 32579268
Nature. 2020 Nov;587(7833):270-274
pubmed: 32726801
J Immunol Res. 2015;2015:763461
pubmed: 26568965
Cell Host Microbe. 2020 Apr 8;27(4):671-680.e2
pubmed: 32183941
Nat Immunol. 2020 Nov;21(11):1336-1345
pubmed: 32887977
Annu Rev Immunol. 2004;22:745-63
pubmed: 15032595
Immunity. 2020 Jun 16;52(6):971-977.e3
pubmed: 32413330
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):769-74
pubmed: 24367104