Relationship Between ACE2 and Other Components of the Renin-Angiotensin System.

Angiotensin-Converting Enzyme 2 Betacoronavirus COVID-19 Coronavirus Infections / physiopathology Humans Pandemics Peptidyl-Dipeptidase A / physiology Pneumonia, Viral / physiopathology Receptors, Virus / physiology Renin-Angiotensin System SARS-CoV-2
Angiotensin receptor blockers Angiotensin-converting enzyme Angiotensin-converting enzyme inhibitors COVID-19 Cardiovascular disease Chronic kidney disease Coronavirus infections Hypertension Renin-angiotensin system

Journal

Current hypertension reports
ISSN: 1534-3111
Titre abrégé: Curr Hypertens Rep
Pays: United States
ID NLM: 100888982

Informations de publication

Date de publication:
26 06 2020
Historique:
entrez: 28 6 2020
pubmed: 28 6 2020
medline: 9 7 2020
Statut: epublish

Résumé

Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection. ACE2 converts angiotensin (Ang) II to Ang-(1-7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.

Identifiants

DOI: 10.1007/s11906-020-01048-y PMID: 32591908 PMC: PMC7317893
pubmed: 32591908
doi: 10.1007/s11906-020-01048-y
pii: 10.1007/s11906-020-01048-y
pmc: PMC7317893
mid: NIHMS1607741
doi:

Substances chimiques

Receptors, Virus 0
Peptidyl-Dipeptidase A EC 3.4.15.1
ACE2 protein, human EC 3.4.17.23
Angiotensin-Converting Enzyme 2 EC 3.4.17.23

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

44

Subventions

Organisme : NHLBI NIH HHS
ID : T32 HL007891
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL133843
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146818
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL133468
Pays : United States
Organisme : NHLBI NIH HHS
ID : L40 HL148910
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK108173
Pays : United States

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Auteurs

Jordana B Cohen (JB)

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jco@pennmedicine.upenn.edu.
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jco@pennmedicine.upenn.edu.

Thomas C Hanff (TC)

Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Adam P Bress (AP)

Division of Health System Innovation and Research, Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.

Andrew M South (AM)

Section of Nephrology, Department of Pediatrics, Wake Forest School of Medicine and Brenner Children's Hospital, Winston Salem, USA.
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, USA.
Department of Surgery-Hypertension and Vascular Research, Wake Forest School of Medicine, Winston Salem, NC, USA.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Carboxypeptidases › Angiotensin-converting enzyme 2 › Relationship Between ACE2 and Other Components...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Relationship Between ACE2 and Other Components...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Relationship Between ACE2 and Other Components...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Nidovirales › Infections à Coronaviridae › Infections à coronavirus › Relationship Between ACE2 and Other Components...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Relationship Between ACE2 and Other Components...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Épidémies de maladies › Épidémies › Pandémies › Relationship Between ACE2 and Other Components...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Dipeptidyl-Peptidases and Tripeptidyl-Peptidases › Peptidyl-Dipeptidase A › Relationship Between ACE2 and Other Components...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › Relationship Between ACE2 and Other Components...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Relationship Between ACE2 and Other Components...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Système rénine-angiotensine › Relationship Between ACE2 and Other Components...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Relationship Between ACE2 and Other Components...