Spanish multicenter study of surgical resection of pancreatic tumors infiltrating the celiac axis: does the type of pancreatectomy affect results?
Body Mass Index
Celiac Artery
/ surgery
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Lymph Node Excision
/ statistics & numerical data
Male
Middle Aged
Neoplasm Invasiveness
/ pathology
Operative Time
Pancreatectomy
/ adverse effects
Pancreatic Neoplasms
/ mortality
Postoperative Complications
Retrospective Studies
Spain
Treatment Outcome
Arterial
Cancer
DP-CAR
Distal pancreatectomy
Embolization
PHAE
Pancreas
Pancreatoduodenectomy
Review
Surgery
Total pancreatectomy
Journal
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
ISSN: 1699-3055
Titre abrégé: Clin Transl Oncol
Pays: Italy
ID NLM: 101247119
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
06
04
2020
accepted:
05
06
2020
pubmed:
28
6
2020
medline:
28
8
2021
entrez:
28
6
2020
Statut:
ppublish
Résumé
Pancreatectomy plus celiac axis resection (CAR) is performed in patients with locally advanced pancreatic cancer. The morbidity rates are high, and no survival benefit has been confirmed. It is not known at present whether it is the type of pancreatectomy, or CAR itself, that is the reason for the high complication rates. Observational retrospective multicenter study. patient undergoing TP, PD or DP plus CAR for a pancreatic cancer. Sixty-two patients who had undergone pancreatic cancer surgery (PD,TP or DP) plus CAR were studied. Group 1: 17 patients who underwent PD/TP-CAR (13TP/4PD); group 2: 45 patients who underwent DP-CAR. Groups were mostly homogeneous. Operating time was longer in the PD/TP group, while operative complications did not differ statistically in the two groups. The number of lymph nodes removed was higher in the PD/TP group (26.5 vs 17.3), and this group also had a higher positive node ratio (17.9% vs 7.6%). There were no statistical differences in total or disease-free survival between the two groups. It seems that CAR, and not the type of pancreatectomy, influences morbidity and mortality in this type of surgery. International multicenter studies with larger numbers of patients are now needed to validate the data presented here.
Sections du résumé
BACKGROUND
BACKGROUND
Pancreatectomy plus celiac axis resection (CAR) is performed in patients with locally advanced pancreatic cancer. The morbidity rates are high, and no survival benefit has been confirmed. It is not known at present whether it is the type of pancreatectomy, or CAR itself, that is the reason for the high complication rates.
METHODS
METHODS
Observational retrospective multicenter study.
INCLUSION CRITERIA
METHODS
patient undergoing TP, PD or DP plus CAR for a pancreatic cancer.
RESULTS
RESULTS
Sixty-two patients who had undergone pancreatic cancer surgery (PD,TP or DP) plus CAR were studied. Group 1: 17 patients who underwent PD/TP-CAR (13TP/4PD); group 2: 45 patients who underwent DP-CAR. Groups were mostly homogeneous. Operating time was longer in the PD/TP group, while operative complications did not differ statistically in the two groups. The number of lymph nodes removed was higher in the PD/TP group (26.5 vs 17.3), and this group also had a higher positive node ratio (17.9% vs 7.6%). There were no statistical differences in total or disease-free survival between the two groups.
CONCLUSION
CONCLUSIONS
It seems that CAR, and not the type of pancreatectomy, influences morbidity and mortality in this type of surgery. International multicenter studies with larger numbers of patients are now needed to validate the data presented here.
Identifiants
pubmed: 32592157
doi: 10.1007/s12094-020-02423-6
pii: 10.1007/s12094-020-02423-6
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
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