Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin.

Animals Arachidonic Acid / administration & dosage Aspirin / pharmacology Blood Platelets / drug effects Cyclooxygenase 1 / physiology Cyclooxygenase Inhibitors / pharmacology Eicosanoids / metabolism Female Male Membrane Proteins / physiology Mice Mice, Inbred C57BL Mice, Knockout Thrombosis / drug therapy
antithrombotic therapy aspirin eicosanoid profiling endothelium platelets

Journal

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484

Informations de publication

Date de publication:
08 2020
Historique:
received: 17 02 2020
revised: 06 05 2020
accepted: 07 05 2020
pubmed: 28 6 2020
medline: 2 3 2021
entrez: 28 6 2020
Statut: ppublish

Résumé

Aspirin prevents thrombosis by inhibiting platelet cyclooxygenase (COX)-1 activity and the production of thromboxane (Tx)A

Identifiants

DOI: 10.1096/fj.202000312R PMID: 32592197 PMC: PMC9359103
pubmed: 32592197
doi: 10.1096/fj.202000312R
pmc: PMC9359103
mid: NIHMS1825952
doi:

Substances chimiques

Cyclooxygenase Inhibitors 0
Eicosanoids 0
Membrane Proteins 0
Arachidonic Acid 27YG812J1I
Cyclooxygenase 1 EC 1.14.99.1
Ptgs1 protein, mouse EC 1.14.99.1
Aspirin R16CO5Y76E

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10027-10040

Subventions

Organisme : British Heart Foundation
ID : PG/15/79/31777
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/17/40/33028
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : Z01 ES025034
Pays : United States
Organisme : British Heart Foundation
ID : FS/16/1/31699
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : Z99 ES999999
Pays : United States

Informations de copyright

© 2020 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.

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Auteurs

Marilena Crescente (M)

Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Paul C Armstrong (PC)

Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Nicholas S Kirkby (NS)

National Heart & Lung Institute, Imperial College London, London, UK.

Matthew L Edin (ML)

Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

Melissa V Chan (MV)

Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Fred B Lih (FB)

Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

Jing Jiao (J)

Department of Medical and Molecular Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Tania Maffucci (T)

Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Harriet E Allan (HE)

Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Charles A Mein (CA)

Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Carles Gaston-Massuet (C)

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Graeme S Cottrell (GS)

Reading School of Pharmacy and ICMR, University of Reading, Reading, UK.

Jane A Mitchell (JA)

National Heart & Lung Institute, Imperial College London, London, UK.

Darryl C Zeldin (DC)

Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

Harvey R Herschman (HR)

Department of Medical and Molecular Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Timothy D Warner (TD)

Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
ORCID: 0000-0003-3988-4408

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Profiling the eicosanoid networks that...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras indispensables › Acides arachidoniques › Acide arachidonique › Profiling the eicosanoid networks that...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Hydroxybenzoates › Salicylates › Acide acétylsalicylique › Profiling the eicosanoid networks that...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Plaquettes › Profiling the eicosanoid networks that...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Cyclooxygenase 1 › Profiling the eicosanoid networks that...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antirhumatismaux › Anti-inflammatoires non stéroïdiens › Inhibiteurs des cyclooxygénases › Profiling the eicosanoid networks that...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Profiling the eicosanoid networks that...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Profiling the eicosanoid networks that...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Profiling the eicosanoid networks that...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Profiling the eicosanoid networks that...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Profiling the eicosanoid networks that...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thrombose › Profiling the eicosanoid networks that...