Immune response in children with COVID-19 is characterized by lower levels of T-cell activation than infected adults.
Adolescent
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
COVID-19
/ blood
Chemokine CCL2
/ blood
Chemokine CCL5
/ blood
Chemokine CXCL10
/ blood
Chemokine CXCL9
/ blood
Chemokines
/ blood
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Interleukin-8
/ blood
Lymphocyte Activation
Lymphocyte Count
Lymphopenia
/ pathology
Male
SARS-CoV-2
/ immunology
T-Lymphocyte Subsets
/ immunology
CCL5/RANTES
COVID-19
CXCL9/MIG
SARS-CoV-2
T-cell activation
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
28
04
2020
revised:
17
06
2020
accepted:
26
06
2020
pubmed:
28
6
2020
medline:
18
12
2020
entrez:
28
6
2020
Statut:
ppublish
Résumé
Study of immunological features of immune response in 14 children (aged from 12 days up to 15 years) and of 10 adults who developed COVID-19 show increased number of activated CD4 and CD8 cells expressing DR and higher plasmatic levels of IL-12 and IL-1β in adults with COVID-19, but not in children. In addition, plasmatic levels of CCL5/RANTES are higher in children and adults with COVID-19, while CXCL9/MIG was only increased in adults. Higher number of activated T cells and expression of IL-12 and CXCL9 suggest prominent Th1 polarization of immune response against SARS-CoV2 in infected adults as compared with children.
Identifiants
pubmed: 32592406
doi: 10.1002/eji.202048724
pmc: PMC7361574
doi:
Substances chimiques
CCL2 protein, human
0
CCL5 protein, human
0
CXCL10 protein, human
0
CXCL8 protein, human
0
CXCL9 protein, human
0
Chemokine CCL2
0
Chemokine CCL5
0
Chemokine CXCL10
0
Chemokine CXCL9
0
Chemokines
0
Interleukin-8
0
Types de publication
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1412-1414Subventions
Organisme : University of Brescia
Pays : International
Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Références
J Virol. 2006 Aug;80(16):8151-7
pubmed: 16873271
N Engl J Med. 2020 Apr 2;382(14):1370-1371
pubmed: 32163697