Pons Anteroposterior and Cerebellar Vermis Craniocaudal Diameters in Fetuses With Down Syndrome.
Down syndrome
fetal pons
fetal vermis
ultrasound
Journal
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
ISSN: 1550-9613
Titre abrégé: J Ultrasound Med
Pays: England
ID NLM: 8211547
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
28
04
2020
revised:
20
05
2020
accepted:
01
06
2020
pubmed:
28
6
2020
medline:
29
4
2021
entrez:
28
6
2020
Statut:
ppublish
Résumé
To investigate the pons anteroposterior diameter (APD) and cerebellar vermis craniocaudal diameter (CCD) of fetuses with Down syndrome (DS). This was a prospective observational study including 200 low-risk pregnancies and 18 pregnancies with fetuses who had DS. A midsagittal view was obtained to measure the pons APD and cerebellar vermis CCD. Gestational age-related 5th, mean, and 95th percentiles for the pons APD and cerebellar vermis CCD between 18 and 32 weeks' gestation were created from the low-risk population. Each measurement of a fetus with DS was plotted on growth charts, and those below the 5th percentile for gestational age were considered small. The pons APD and cerebellar vermis CCD measurements were below the 5th percentile for gestational age in 7 of the 18 (38.8%) fetuses with DS. Fetuses who had pons APDs below the 5th percentile for gestational age also had cerebellar vermis CCDs below the 5th percentile. Fetuses who had pons and cerebellar vermis measurements below the 5th percentile for gestational age on the initial examination continued to have small measurements during follow-up. Fetal pons and cerebellar vermis abnormalities could be observed prenatally in fetuses with DS, which could help in the antenatal counseling and postnatal follow-up of such pregnancies.
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
123-128Informations de copyright
© 2020 American Institute of Ultrasound in Medicine.
Références
Daunhauer LA, Fidler DJ, Hahn L, Will E, Lee NR, Hepburn S. Profiles of everyday executive functioning in young children with Down syndrome. Am J Intellect Dev Disabil 2014; 119:303-318.
Roizen NJ, Patterson D. Down's syndrome. Lancet 2003; 361:1281-1289.
Crome L, Cowie V, Slater E. A statistical note on cerebellar and brain-stem weight in mongolism. J Intellect Disabil Res 1966; 10:69-72.
Pinter JD, Eliez S, Schmitt JE, Capone GT, Reiss AL. Neuroanatomy of Down's syndrome: a high-resolution MRI study. Am J Psychiatry 2001; 158:1659-1665.
Coyle JT, Oster-Granite M, Gearhart JD. The neurobiologic consequences of Down syndrome. Brain Res Bull 1986; 16:773-787.
Romito JW, Bhoja R, McDonagh DL. Central and peripheral nervous systems. In: Farag E, Argalious M, Tetzlaff J, Sharma D (eds). Basic Sciences in Anesthesia. Chaim, Switzerland: Springer; 2018:271-297.
Fujii Y, Aida N, Niwa T, Enokizono M, Nozawa K, Inoue T. A small pons as a characteristic finding in Down syndrome: a quantitative MRI study. Brain Dev 2017; 39:298-305.
Mirlesse V, Courtiol C, Althuser M, Duyme M. Ultrasonography of the fetal brainstem: a biometric and anatomical, multioperator, cross-sectional study of 913 fetuses of 21-36 weeks of gestation. Prenat Diagn 2010; 30:739-745.
Ginath S, Lerman-Sagie T, Haratz Krajden K, et al. The fetal vermis, pons and brainstem: normal longitudinal development as shown by dedicated neurosonography. J Matern Fetal Neonatal Med 2013; 26:757-762.
Wisniewski K. Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis. Am J Med Genet Suppl 1990; 37:274-281.
Rotmensch S, Goldstein I, Liberati M, Shalev J, Ben-Rafael Z, Copel JA. Fetal transcerebellar diameter in Down syndrome. Obstet Gynecol 1997; 89:534-537.
Winter TC, Ostrovsky AA, Komarniski CA, Uhrich SB. Cerebellar and frontal lobe hypoplasia in fetuses with trisomy 21: usefulness as combined US markers. Radiology 2000; 214:533-588.
Achiron R, Kivilevitch Z, Lipitz S, Gamzu R, Almog B, Zalel Y. Development of the human fetal pons: in utero ultrasonographic study. Ultrasound Obstet Gynecol 2004; 24:506-510.
Ieshima A, Kisa T, Yoshino K, Takashima S, Takeshita K. A morphometric CT study of Down's syndrome showing small posterior fossa and calcification of basal ganglia. Neuroradiology 1984; 26:493-498.
Dierssen M. Down syndrome: the brain in trisomic mode. Nat Rev Neurosci 2012; 13:844-858.
Mégarbané A, Ravel A, Mircher C, et al. The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genet Med 2009; 11:611-616.
Lott IT, Dierssen M. Cognitive deficits and associated neurological complications in individuals with Down's syndrome. Lancet Neurol 2010; 9:623-633.
Lott IT. Neurological phenotypes for Down syndrome across the life span. Prog Brain Res 2012; 197:101-121.
Frith U, Frith CD. Specific motor disabilities in Down's syndrome. J Child Psychol Psychiatry 1974; 15:293-301.