Ursolic acid has no additional effect on muscle strength and mass in active men undergoing a high-protein diet and resistance training: A double-blind and placebo-controlled trial.
Hypertrophy
Muscle mass
Muscle strength
Ursolic acid
Journal
Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
08
09
2019
revised:
29
05
2020
accepted:
05
06
2020
pubmed:
1
7
2020
medline:
24
8
2021
entrez:
29
6
2020
Statut:
ppublish
Résumé
Ursolic acid (UA) is thought to have an anabolic effect on muscle mass in humans. This study sought to compare the effects of UA and a placebo on muscle strength and mass in young men undergoing resistance training (RT) and consuming a high-protein diet. A clinical, double-blind, placebo-controlled trial was conducted for 8 weeks. The Control + RT group (CON n = 12) received 400 mg/d of placebo, and the UA + RT group (UA n = 10) received 400 mg/d of UA. Both groups ingested ~1.6 g/kg of protein and performed the same RT program. Pre- and post-intervention, both groups were evaluated for anthropometric measures, body composition, food intake and muscle strength. Food intake remained unchanged throughout the study. Both groups showed significant increases in body weight (CON Δ: 2.12 ± 0.47 kg, p = 0.001 vs. UA Δ: 2.24 ± 0.67 kg, p = 0.009), body mass index (BMI) (CON Δ: 0.69 ± 0.15 kg/m Ursolic acid had no synergic effect on muscle strength and mass in response to RT in physically active men consuming a high-protein diet. RBR-76tbqs.
Sections du résumé
BACKGROUND
Ursolic acid (UA) is thought to have an anabolic effect on muscle mass in humans. This study sought to compare the effects of UA and a placebo on muscle strength and mass in young men undergoing resistance training (RT) and consuming a high-protein diet.
METHODS
A clinical, double-blind, placebo-controlled trial was conducted for 8 weeks. The Control + RT group (CON n = 12) received 400 mg/d of placebo, and the UA + RT group (UA n = 10) received 400 mg/d of UA. Both groups ingested ~1.6 g/kg of protein and performed the same RT program. Pre- and post-intervention, both groups were evaluated for anthropometric measures, body composition, food intake and muscle strength.
RESULTS
Food intake remained unchanged throughout the study. Both groups showed significant increases in body weight (CON Δ: 2.12 ± 0.47 kg, p = 0.001 vs. UA Δ: 2.24 ± 0.67 kg, p = 0.009), body mass index (BMI) (CON Δ: 0.69 ± 0.15 kg/m
CONCLUSIONS
Ursolic acid had no synergic effect on muscle strength and mass in response to RT in physically active men consuming a high-protein diet.
BRAZILIAN CLINICAL TRIALS REGISTRY (REBEC)
RBR-76tbqs.
Identifiants
pubmed: 32593524
pii: S0261-5614(20)30294-6
doi: 10.1016/j.clnu.2020.06.004
pii:
doi:
Substances chimiques
Triterpenes
0
Banques de données
ReBec
['RBR-76tbqs']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
581-589Informations de copyright
Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of Interest The authors declare no conflict of interest.