Islet, thyroid and transglutaminase antibodies in adult Bulgarian patients with type 1 diabetes.
Autoimmune thyroid disease
Autoimmunity
Celiac disease
Islet antibodies
Type 1 diabetes
Journal
Endocrine
ISSN: 1559-0100
Titre abrégé: Endocrine
Pays: United States
ID NLM: 9434444
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
28
02
2020
accepted:
18
06
2020
pubmed:
1
7
2020
medline:
22
6
2021
entrez:
29
6
2020
Statut:
ppublish
Résumé
The aim of the study was to assess the prevalence and relationship of islet antibodies and autoantibodies of the most common associated autoimmune diseases-autoimmune thyroid disease (AITD) and celiac disease, in adult Bulgarian patients with type 1 diabetes of short duration. 160 type 1 diabetes patients, of mean age 36.3 ± 10.9 years, mean BMI 23.0 ± 4.2 kg/m 87.5% of the patients had one or more of the islet antibodies-78.1% had GAD 65-Ab, 53.1%-ZnT8-Ab, and 34.4%-IA 2-Ab. 5% presented as just ZnT8-Ab positive. GAD 65-Ab identified 90.6% of the antibody positive patients. The addition of IA 2-Ab as a second immunologic marker identified 94.4%, while the use of ZnT8-Ab in second place identified 98.8% of the cases. 24.4% presented with positive thyroid antibodies and 33.8% had AITD. No relation was found between any of the islet antibodies and AITD. None of the patients was TTG-IgA-Ab positive. No significant correlations were established between the antibodies with different organ specificity. In adult Bulgarian type 1 diabetes patients ZnT8-Ab is an independent diagnostic marker rating second in prevalence and diagnostic significance after GAD 65-Ab. AITD affects about one third of this population and routine screening is required, while screening for celiac disease is not justified.
Identifiants
pubmed: 32594378
doi: 10.1007/s12020-020-02395-1
pii: 10.1007/s12020-020-02395-1
doi:
Substances chimiques
Autoantibodies
0
Transglutaminases
EC 2.3.2.13
Glutamate Decarboxylase
EC 4.1.1.15
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
299-306Subventions
Organisme : Medical University Sofia
ID : D-113/2018.
Pays : International
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