TGIF1 and SF1 polymorphisms are associated with litter size in Small Tail Han sheep.
SF1
TGIF1
SNPs
litter size
sheep
Journal
Reproduction in domestic animals = Zuchthygiene
ISSN: 1439-0531
Titre abrégé: Reprod Domest Anim
Pays: Germany
ID NLM: 9015668
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
12
04
2020
revised:
05
06
2020
accepted:
15
06
2020
pubmed:
1
7
2020
medline:
16
7
2021
entrez:
29
6
2020
Statut:
ppublish
Résumé
TGF-β induced factor homeobox 1 (TGIF1) and splicing factor 1 (SF1) are important for mammalian reproduction; however, the effects of these genes on litter size in sheep remain unexplored. In this study, we genotyped 768 ewes from seven sheep breeds at two loci: g.37871539C>T, a synonymous mutation of TGIF1; and g.42314637T>C, a 3'UTR variant of SF1. Our analysis of polymorphism revealed only two genotypes at locus g.37871539C>T in TGIF1, with most sheep populations being moderately polymorphic (0.25 < PIC < 0.5) at this site. In contrast, most breeds exhibited low polymorphism (PIC ≤0.25) at the SF1 locus g.42314637T>C. The association analysis revealed that a synonymous mutation at g.37871539C>T in TGIF1 was highly associated with litter size in Small Tail Han sheep, in which it causes a significant decrease in litter size. Conversely, while the SF1 3'UTR variant g.42314637T>C was also highly associated with litter size in sheep, it causes a significant increase in the number of litter size. Combined, these data provide valuable information regarding candidate genetic markers for sheep breeding programs.
Identifiants
pubmed: 32594576
doi: 10.1111/rda.13753
pmc: PMC7540012
doi:
Substances chimiques
RNA Splicing Factors
0
Transforming Growth Factor beta
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1145-1153Subventions
Organisme : National Natural Science Foundation of China
ID : 31861143012
Organisme : National Natural Science Foundation of China
ID : 31772580
Organisme : Genetically Modified Organisms Breeding Major Program of China
ID : 2016ZX08009-003-006
Organisme : Earmarked Fund for China Agriculture Research System
ID : CARS-38
Organisme : Central Public-Interest Scientific Institution Basal Research Fund
ID : Y2017JC24
Organisme : Agricultural Science and Technology Innovation Program of China
ID : ASTIP-IAS13
Organisme : Agricultural Science and Technology Innovation Program of China
ID : CAAS-XTCX2016011-02-02
Organisme : China Agricultural Scientific Research Outstanding Talents and Their Innovative Teams Program
Organisme : China High-level Talents Special Support Plan Scientific and Technological Innovation Leading Talents Program
ID : W02020274
Organisme : Tianjin Agricultural Science and Technology Achievements Transformation and Popularization Program
ID : 201704020
Informations de copyright
© 2020 The Authors. Reproduction in Domestic Animals published by Blackwell Verlag GmbH.
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