A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation.
EMT
axial elongation
axial progenitors
developmental biology
mouse
snai1
tail bud
tgfbr1
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
29 06 2020
29 06 2020
Historique:
received:
03
03
2020
accepted:
18
06
2020
entrez:
30
6
2020
pubmed:
1
7
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Formation of the vertebrate postcranial body axis follows two sequential but distinct phases. The first phase generates pre-sacral structures (the so-called primary body) through the activity of the primitive streak on axial progenitors within the epiblast. The embryo then switches to generate the secondary body (post-sacral structures), which depends on axial progenitors in the tail bud. Here we show that the mammalian tail bud is generated through an independent functional developmental module, concurrent but functionally different from that generating the primary body. This module is triggered by convergent Tgfbr1 and Snai1 activities that promote an incomplete epithelial to mesenchymal transition on a subset of epiblast axial progenitors. This EMT is functionally different from that coordinated by the primitive streak, as it does not lead to mesodermal differentiation but brings axial progenitors into a transitory state, keeping their progenitor activity to drive further axial body extension.
Identifiants
pubmed: 32597756
doi: 10.7554/eLife.56615
pii: 56615
pmc: PMC7324159
doi:
pii:
Substances chimiques
Snai1 protein, mouse
0
Snail Family Transcription Factors
0
Receptor, Transforming Growth Factor-beta Type I
EC 2.7.11.30
Tgfbr1 protein, mouse
EC 2.7.11.30
Banques de données
GEO
['GSE147100', 'GSE120870']
SRA
['SRX4968732', 'SRX4968731', 'SRX5532193', 'SRX5532192']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/S008799/1
Pays : United Kingdom
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/BEX-BID/0899/2014
Pays : International
Organisme : Fundação para a Ciência e a Tecnologia
ID : LISBOA-01-0145-FEDER-030254
Pays : International
Organisme : Company of Biologists
ID : DEV-170806
Pays : International
Organisme : Fundação para a Ciência e a Tecnologia
ID : LISBOA-01-0145-FEDER-022170
Pays : International
Organisme : Medical Research Council
ID : MR/K011200/1
Pays : United Kingdom
Organisme : Santa Casa da Misericórdia
ID : SCML-MC-60-2014
Pays : International
Organisme : Medical Research Council
ID : MR/K017047/1
Pays : United Kingdom
Organisme : Fundação para a Ciência e a Tecnologia
ID : PD/BD/128437/2017
Pays : International
Organisme : Fundação para a Ciência e a Tecnologia
ID : PD/BD/128426/2017
Pays : International
Informations de copyright
© 2020, Dias et al.
Déclaration de conflit d'intérêts
AD, AL, FW, AN, AB, DS, GM, VW, MM No competing interests declared
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