Transient Global Amnesia: A Diffusion and Perfusion MRI study.
Arterial spin labeling
diffusion-weighted image
neurite orientation dispersion and density imaging (NODDI)
transient global amnesia
Journal
Journal of neuroimaging : official journal of the American Society of Neuroimaging
ISSN: 1552-6569
Titre abrégé: J Neuroimaging
Pays: United States
ID NLM: 9102705
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
01
05
2020
revised:
06
06
2020
accepted:
08
06
2020
pubmed:
1
7
2020
medline:
4
6
2021
entrez:
30
6
2020
Statut:
ppublish
Résumé
Transient global amnesia (TGA) is a rare clinical entity with a sudden onset of anterograde amnesia that recovers within 24 hours. The underlying pathophysiology is uncertain. Imaging studies are controversial, but diffusion-weighted images often show small diffusion-restricted lesions in the hippocampus, which may suggest ischemic damage. Thus, we conducted the first clinical study using neurite orientation dispersion and density imaging (NODDI) and arterial spin labeling (ASL) to examine whether the microstructure and perfusion status of the hippocampus are influenced by the presence of diffusion-restricted lesions. Ten patients with a clinical diagnosis of TGA were evaluated by conventional MRI, NODDI, and ASL. The intracellular volume fraction (ICVF) and orientation dispersion index (ODI) on NODDI and cerebral blood flow (CBF) determined by ASL in the hippocampus were calculated and compared by diffusion-weighted imaging (DWI) positivity. Correlations among ICVF, ODI, and CBF were also analyzed. Three patients had typical unilateral DWI-positive lesions. No significant differences in any of the three parameters were detected between DWI-positive and DWI-negative hippocampi. A statistically significant correlation was detected between the ODI and CBF (R = .51, P = .021). The first NODDI and ASL study in patients after TGA demonstrated no obvious microstructural or perfusion abnormalities in the hippocampus with typical DWI-positive lesions, which may indicate that TGA does not cause destructive damage or involve baseline microstructure or perfusion abnormalities in the hippocampus in relation to diffusion-restricted lesions.
Sections du résumé
BACKGROUND AND PURPOSE
Transient global amnesia (TGA) is a rare clinical entity with a sudden onset of anterograde amnesia that recovers within 24 hours. The underlying pathophysiology is uncertain. Imaging studies are controversial, but diffusion-weighted images often show small diffusion-restricted lesions in the hippocampus, which may suggest ischemic damage. Thus, we conducted the first clinical study using neurite orientation dispersion and density imaging (NODDI) and arterial spin labeling (ASL) to examine whether the microstructure and perfusion status of the hippocampus are influenced by the presence of diffusion-restricted lesions.
METHODS
Ten patients with a clinical diagnosis of TGA were evaluated by conventional MRI, NODDI, and ASL. The intracellular volume fraction (ICVF) and orientation dispersion index (ODI) on NODDI and cerebral blood flow (CBF) determined by ASL in the hippocampus were calculated and compared by diffusion-weighted imaging (DWI) positivity. Correlations among ICVF, ODI, and CBF were also analyzed.
RESULTS
Three patients had typical unilateral DWI-positive lesions. No significant differences in any of the three parameters were detected between DWI-positive and DWI-negative hippocampi. A statistically significant correlation was detected between the ODI and CBF (R = .51, P = .021).
CONCLUSIONS
The first NODDI and ASL study in patients after TGA demonstrated no obvious microstructural or perfusion abnormalities in the hippocampus with typical DWI-positive lesions, which may indicate that TGA does not cause destructive damage or involve baseline microstructure or perfusion abnormalities in the hippocampus in relation to diffusion-restricted lesions.
Substances chimiques
Spin Labels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
828-832Informations de copyright
© 2020 American Society of Neuroimaging.
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