Hormones and thrombosis: risk across the reproductive years and beyond.
Journal
Translational research : the journal of laboratory and clinical medicine
ISSN: 1878-1810
Titre abrégé: Transl Res
Pays: United States
ID NLM: 101280339
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
28
02
2020
revised:
18
06
2020
accepted:
24
06
2020
pubmed:
1
7
2020
medline:
21
10
2020
entrez:
30
6
2020
Statut:
ppublish
Résumé
Endogenous and exogenous hormones have significant effects on coagulation and may tip the hemostatic balance toward thrombosis. The endogenous hormonal changes in pregnancy and polycystic ovary syndrome, and exogenous hormonal contraception, menopause replacement, and transgender cross-hormone replacement may increase thromboembolism risk. Using the lowest effective dose is critical for prevention, but once thrombosis occurs, anticoagulation may be required, in some, long term. We review the relative risk of thrombosis in these conditions, risk factors, and anticoagulation treatment and prevention. Implementation of lowest effective hormonal therapies, thrombosis reduction strategies, and current anticoagulation management are critical for optimal patient outcomes.
Identifiants
pubmed: 32599096
pii: S1931-5244(20)30150-X
doi: 10.1016/j.trsl.2020.06.011
pii:
doi:
Substances chimiques
Hormones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-19Subventions
Organisme : NCRR NIH HHS
ID : UL1 RR024153
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000056
Pays : United States
Organisme : NHLBI NIH HHS
ID : R34 HL105870
Pays : United States
Organisme : NHLBI NIH HHS
ID : T35 HL074708
Pays : United States
Organisme : NHLBI NIH HHS
ID : U34 HL114674
Pays : United States
Organisme : NHLBI NIH HHS
ID : U34 HL119582
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL068429
Pays : United States
Organisme : NHLBI NIH HHS
ID : K12 HL087064
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL133815
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000005
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL112614
Pays : United States
Organisme : NCRR NIH HHS
ID : TL1 RR024155
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL061937
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL081588
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.