5XFAD mice show early-onset gap encoding deficits in the auditory cortex.
5XFAD
Auditory cortex
Biomarker
Gap detection
Temporal processing
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
11
12
2019
revised:
19
05
2020
accepted:
24
05
2020
pubmed:
1
7
2020
medline:
30
6
2021
entrez:
30
6
2020
Statut:
ppublish
Résumé
Early detection will be crucial for effective treatment or prevention of Alzheimer's disease. The identification and validation of early, noninvasive biomarkers is therefore key to avoiding the most devastating aspects of Alzheimer's disease. Measures of central auditory processing such as gap detection have recently emerged as potential biomarkers in both human patients and the 5XFAD mouse model of Alzheimer's disease. Full validation of gap detection deficits as a biomarker will require detailed understanding of the underlying neuropathology, including which brain structures are involved and how the operation of neural circuits is affected. Here we show that 5XFAD mice exhibit gap detection deficits as early as 2 months of age, well before development of Alzheimer's disease-associated pathology. We then examined responses of neurons in the auditory cortex to gaps in white noise. Both gap responses and baseline firing rates were robustly and progressively degraded in 5XFAD mice compared to littermate controls. These impairments were first evident at 2-4 months of age in males, and 4-6 months in females. This demonstrates early-onset impairments to the central auditory system, which could be due to damage in the auditory cortex, upstream subcortical structures, or both.
Identifiants
pubmed: 32599514
pii: S0197-4580(20)30175-5
doi: 10.1016/j.neurobiolaging.2020.05.013
pmc: PMC7483957
mid: NIHMS1607509
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-110Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC015828
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Références
Cereb Cortex. 2020 May 18;30(6):3590-3607
pubmed: 32055848
Hear Res. 2016 Nov;341:109-118
pubmed: 27562195
Front Behav Neurosci. 2019 May 17;13:107
pubmed: 31156407
J Comp Neurol. 2019 Feb 1;527(2):462-475
pubmed: 30291623
Arch Otolaryngol Head Neck Surg. 2011 Apr;137(4):390-5
pubmed: 21502479
Eur J Neurosci. 2010 Jan;31(1):110-8
pubmed: 20092558
Neuroreport. 2015 May 6;26(7):411-5
pubmed: 25830491
Alzheimers Res Ther. 2017 Oct 4;9(1):80
pubmed: 28978359
Neurosci Lett. 1989 Jan 2;96(1):60-3
pubmed: 2648201
Neurobiol Learn Mem. 2009 Oct;92(3):455-9
pubmed: 19435612
Neuron. 2018 Dec 5;100(5):1028-1043
pubmed: 30521778
Eur J Neurosci. 2006 Jan;23(1):251-60
pubmed: 16420434
J Am Geriatr Soc. 2002 Mar;50(3):482-8
pubmed: 11943044
Psychiatr Times. 2018 Nov;35(11):14-17
pubmed: 30820070
Age Ageing. 2011 Mar;40(2):249-54
pubmed: 21233090
Nat Rev Neurol. 2018 Aug;14(8):457-469
pubmed: 29985474
Lancet. 2005 Sep 24-30;366(9491):1111-20
pubmed: 16182900
Cereb Cortex. 2003 Aug;13(8):815-22
pubmed: 12853367
Behav Neurosci. 1990 Dec;104(6):831-40
pubmed: 2285482
J Comp Neurol. 2004 Nov 1;479(1):103-16
pubmed: 15389608
Behav Neurosci. 1991 Feb;105(1):33-40
pubmed: 2025392
Neurosci Lett. 2020 Jan 19;717:134705
pubmed: 31870800
Am J Ophthalmol. 2009 Apr;147(4):571-2
pubmed: 19327444
Curr Alzheimer Res. 2014;11(5):450-60
pubmed: 24801216
Contrast Media Mol Imaging. 2018 Feb 28;2018:5272014
pubmed: 29681782
Hear Res. 1990 Dec;50(1-2):185-92
pubmed: 2076971
J Assoc Res Otolaryngol. 2002 Sep;3(3):321-31
pubmed: 12382106
J Comp Neurol. 2013 Jul 1;521(10):Spc1
pubmed: 23605442
Prog Neurobiol. 1999 Oct;59(2):107-28
pubmed: 10463792
Neuron. 2013 Dec 18;80(6):1347-58
pubmed: 24360540
Neuroscience. 2013 Dec 19;254:152-9
pubmed: 24055684
Front Neurol. 2011 Jul 11;2:42
pubmed: 21808630
Mol Neurodegener. 2014 Apr 02;9:13
pubmed: 24694184
Neurobiol Aging. 2018 Jul;67:181-188
pubmed: 29735432
J Am Acad Audiol. 1996 Jun;7(3):183-9
pubmed: 8780991
J Acoust Soc Am. 1987 May;81(5):1546-56
pubmed: 3584692
Neurology. 1993 Apr;43(4):779-85
pubmed: 8469340
Ageing Res Rev. 2018 Jul;44:49-59
pubmed: 29630950
Genes Brain Behav. 2017 Jun;16(5):554-563
pubmed: 28133939
Brain Struct Funct. 2014 Mar;219(2):571-80
pubmed: 23417057
Neurobiol Aging. 2012 Jan;33(1):196.e29-40
pubmed: 20619937
Curr Biol. 2014 Jul 7;24(13):1447-55
pubmed: 24980499
J Am Acad Audiol. 2017 May;28(5):463-471
pubmed: 28534735
Clin Epidemiol. 2014 Jan 08;6:37-48
pubmed: 24470773
Int J Neurosci. 1989 Oct;48(3-4):325-31
pubmed: 2583949
Hippocampus. 2014 Jul;24(7):762-72
pubmed: 24596271
Neurobiol Dis. 2009 Feb;33(2):229-35
pubmed: 19026746
Front Neural Circuits. 2013 Jan 03;6:114
pubmed: 23316140
Neural Plast. 2016;2016:9802086
pubmed: 27298742
Hear Res. 1999 May;131(1-2):177-94
pubmed: 10355614
J Neurosci. 2006 Oct 4;26(40):10129-40
pubmed: 17021169
PLoS One. 2010 Jan 08;5(1):e8643
pubmed: 20062810
J Acoust Soc Am. 2000 Mar;107(3):1615-26
pubmed: 10738815
Front Aging Neurosci. 2019 Apr 02;11:66
pubmed: 31001105
Behav Neurosci. 1996 Jun;110(3):542-50
pubmed: 8888999
J Neurosci. 2008 Jan 23;28(4):788-97
pubmed: 18216187
Ann Neurol. 2001 Jan;49(1):53-66
pubmed: 11198297
J Alzheimers Dis Rep. 2018 Apr 12;2(1):79-91
pubmed: 30480251
Dement Geriatr Cogn Dis Extra. 2018 Oct 22;8(3):393-401
pubmed: 30483305
J Neurosci. 2017 Mar 29;37(13):3610-3620
pubmed: 28270574
Neurobiol Aging. 2011 Aug;32(8):1452-65
pubmed: 19833411
J Alzheimers Dis. 2017;60(4):1589-1600
pubmed: 28984583
Neuroreport. 2008 May 28;19(8):893-8
pubmed: 18463508
Arch Neurol. 1995 Jun;52(6):626-34
pubmed: 7763213
Neuropathol Appl Neurobiol. 2009 Dec;35(6):532-54
pubmed: 19682326
Mol Neurodegener. 2013 Jan 14;8:2
pubmed: 23316765
J Neurosci. 2014 Nov 12;34(46):15437-45
pubmed: 25392510