Glucose-6-Phosphate Dehydrogenase Deficiency: An Actionable Risk Factor for Patients with COVID-19?
COVID-19
Coronavirus
Glucose-6-phosphate deydrogenase deficiency
Risk factor
Journal
Archives of medical research
ISSN: 1873-5487
Titre abrégé: Arch Med Res
Pays: United States
ID NLM: 9312706
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
01
06
2020
accepted:
04
06
2020
pubmed:
1
7
2020
medline:
15
12
2020
entrez:
1
7
2020
Statut:
ppublish
Résumé
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked mutation that is more prevalent in African, Asian, Latin American and Mediterranean populations. Although most individuals are asymptomatic, exposure to certain food, drugs, or infections can trigger acute hemolytic anemia. Given the potential for coronavirus to trigger oxidative stress, unrecognized G6PD deficiency in the presence of the COVID-19 viral infection may cause hemolytic crisis and worse outcome in affected individuals. Further, since certain drugs that may be used to treat COVID-19 infection may cause hemolytic crisis in individuals with G6PD deficiency, it may be warranted to recommend adding G6PD deficiency to the list of screening elements in a COVID-19 workup for those patients where there is a high suspicion for this genetic mutation.
Identifiants
pubmed: 32600868
pii: S0188-4409(20)30948-6
doi: 10.1016/j.arcmed.2020.06.006
pmc: PMC7275985
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
743-744Informations de copyright
Copyright © 2020 IMSS. Published by Elsevier Inc. All rights reserved.
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