Nausea and vomiting in pregnancy is not just 'morning sickness': data from a prospective cohort study in the UK.
cohort studies
early pregnancy symptoms
morning sickness
nausea and vomiting in pregnancy
pregnancy
pregnancy sickness
Journal
The British journal of general practice : the journal of the Royal College of General Practitioners
ISSN: 1478-5242
Titre abrégé: Br J Gen Pract
Pays: England
ID NLM: 9005323
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
12
12
2019
accepted:
27
01
2020
pubmed:
1
7
2020
medline:
22
6
2021
entrez:
1
7
2020
Statut:
epublish
Résumé
Nausea and vomiting in pregnancy is usually called 'morning sickness'. This is felt by sufferers to trivialise the condition. Symptoms have been described as occurring both before and after noon, but daily symptom patterns have not been clearly described and statistically modelled to enable the term 'morning sickness' to be accurately analysed. To describe the daily variation in nausea and vomiting symptoms during early pregnancy in a group of sufferers. A prospective cohort study of females recruited from 15 May 2014 to 17 February 2017 by Swiss Precision Diagnostics (SPD) Development Company Limited, which was researching hormone levels in early pregnancy and extended its study to include the description of pregnancy symptoms. Daily symptom diaries of nausea and vomiting were kept by females who were trying to conceive. They also provided daily urine samples, which when analysed enabled the date of ovulation to be determined. Data from 256 females who conceived during the first month of the study are included in this article. Daily symptom patterns and changes in daily patterns by week of pregnancy were modelled. Functional data analysis was used to produce estimated symptom probability functions. There was a peak probability of nausea in the morning, a lower but sustained probability of nausea throughout the day, and a slight peak in the evening. Vomiting had a defined peak incidence in the morning. Referring to nausea and vomiting in pregnancy as simply 'morning sickness' is inaccurate, simplistic, and therefore unhelpful.
Sections du résumé
BACKGROUND
Nausea and vomiting in pregnancy is usually called 'morning sickness'. This is felt by sufferers to trivialise the condition. Symptoms have been described as occurring both before and after noon, but daily symptom patterns have not been clearly described and statistically modelled to enable the term 'morning sickness' to be accurately analysed.
AIM
To describe the daily variation in nausea and vomiting symptoms during early pregnancy in a group of sufferers.
DESIGN AND SETTING
A prospective cohort study of females recruited from 15 May 2014 to 17 February 2017 by Swiss Precision Diagnostics (SPD) Development Company Limited, which was researching hormone levels in early pregnancy and extended its study to include the description of pregnancy symptoms.
METHOD
Daily symptom diaries of nausea and vomiting were kept by females who were trying to conceive. They also provided daily urine samples, which when analysed enabled the date of ovulation to be determined. Data from 256 females who conceived during the first month of the study are included in this article. Daily symptom patterns and changes in daily patterns by week of pregnancy were modelled. Functional data analysis was used to produce estimated symptom probability functions.
RESULTS
There was a peak probability of nausea in the morning, a lower but sustained probability of nausea throughout the day, and a slight peak in the evening. Vomiting had a defined peak incidence in the morning.
CONCLUSION
Referring to nausea and vomiting in pregnancy as simply 'morning sickness' is inaccurate, simplistic, and therefore unhelpful.
Identifiants
pubmed: 32601054
pii: bjgp20X710885
doi: 10.3399/bjgp20X710885
pmc: PMC7357866
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e534-e539Informations de copyright
© British Journal of General Practice 2020.
Références
Br J Gen Pract. 1993 Jun;43(371):245-8
pubmed: 8373648
Br J Gen Pract. 2019 Mar;69(680):e217-e223
pubmed: 30559108
Geburtshilfe Frauenheilkd. 2014 Jul;74(7):661-669
pubmed: 25100881
Clin Chem Lab Med. 2015 Jun;53(7):1099-108
pubmed: 25720077
Eur J Contracept Reprod Health Care. 2015;20(6):438-50
pubmed: 26018113
Int J Gynaecol Obstet. 2000 Sep;70(3):359-65
pubmed: 10967171
Birth. 2010 Sep;37(3):237-44
pubmed: 20887540
Aust N Z J Obstet Gynaecol. 2000 Nov;40(4):397-401
pubmed: 11194422
Arch Gynecol Obstet. 2016 Oct;294(4):867-76
pubmed: 27469987