A Roadblock-and-Kill Mechanism of Action Model for the DNA-Targeting Antibiotic Ciprofloxacin.

Anti-Bacterial Agents / pharmacology Ciprofloxacin / pharmacology DNA DNA Gyrase / genetics DNA Topoisomerase IV / genetics DNA Topoisomerases, Type II / genetics DNA, Bacterial / genetics Escherichia coli / genetics Fluoroquinolones Mutation
antibiotics computer modeling fluoroquinolones mechanisms of action

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
20 08 2020
Historique:
received: 12 12 2019
accepted: 19 06 2020
pubmed: 1 7 2020
medline: 22 6 2021
entrez: 1 7 2020
Statut: epublish

Résumé

Fluoroquinolones, antibiotics that cause DNA damage by inhibiting DNA topoisomerases, are clinically important, but their mechanism of action is not yet fully understood. In particular, the dynamical response of bacterial cells to fluoroquinolone exposure has hardly been investigated, although the SOS response, triggered by DNA damage, is often thought to play a key role. Here, we investigated the growth inhibition of the bacterium

Identifiants

DOI: 10.1128/AAC.02487-19 PMID: 32601161 PMC: PMC7449190
pubmed: 32601161
pii: AAC.02487-19
doi: 10.1128/AAC.02487-19
pmc: PMC7449190
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
DNA, Bacterial 0
Fluoroquinolones 0
Ciprofloxacin 5E8K9I0O4U
DNA 9007-49-2
DNA Topoisomerase IV EC 5.99.1.-
DNA Gyrase EC 5.99.1.3
DNA Topoisomerases, Type II EC 5.99.1.3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 American Society for Microbiology.

Références

PLoS Biol. 2005 Jul;3(7):e255
pubmed: 16000023
Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):E4735-42
pubmed: 26261330
J Biol Chem. 1998 Aug 28;273(35):22615-26
pubmed: 9712890
Antimicrob Agents Chemother. 2008 Feb;52(2):385-92
pubmed: 17724149
Cytoskeleton (Hoboken). 2010 Nov;67(11):693-705
pubmed: 20814909
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12783-8
pubmed: 15328417
Antimicrob Agents Chemother. 1997 Feb;41(2):363-73
pubmed: 9021193
J Med Microbiol. 1987 Feb;23(1):83-8
pubmed: 3546699
J Mol Biol. 2000 Dec 15;304(5):779-91
pubmed: 11124026
Cell. 2016 Jul 28;166(3):729-739
pubmed: 27471967
Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92
pubmed: 9293187
Curr Biol. 2015 Feb 2;25(3):385-391
pubmed: 25544609
Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):178-83
pubmed: 25492931
Cell. 2007 Sep 7;130(5):797-810
pubmed: 17803904
J Bacteriol. 1974 Apr;118(1):242-9
pubmed: 4595200
PLoS One. 2009;4(5):e5363
pubmed: 19424504
Antimicrob Agents Chemother. 2006 Sep;50(9):2957-65
pubmed: 16940088
Nature. 2007 Apr 5;446(7136):668-71
pubmed: 17410176
Mol Syst Biol. 2012;8:617
pubmed: 23047527
Trends Microbiol. 2014 Aug;22(8):438-45
pubmed: 24842194
Elife. 2018 Mar 06;7:
pubmed: 29508699
Phys Rev Lett. 2012 Aug 24;109(8):088101
pubmed: 23002776
J Theor Biol. 1997 May 21;186(2):251-60
pubmed: 9196659
Phys Biol. 2017 Nov 16;14(6):065005
pubmed: 28714461
Science. 2013 Mar 8;339(6124):1213-6
pubmed: 23471410
Mol Syst Biol. 2006;2:2006.0008
pubmed: 16738554
Cell. 2009 Nov 13;139(4):707-18
pubmed: 19914165
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12254-9
pubmed: 22773816
PLoS Comput Biol. 2010 Jun 03;6(6):e1000796
pubmed: 20532210
J Theor Biol. 2009 Dec 7;261(3):388-95
pubmed: 19699751
J Clin Invest. 2003 Jul;112(2):275-85
pubmed: 12865415
Annu Rev Genet. 2003;37:611-46
pubmed: 14616075
Antimicrob Agents Chemother. 2006 Jan;50(1):362-4
pubmed: 16377712
PLoS Genet. 2018 Mar 9;14(3):e1007256
pubmed: 29522563
FEMS Microbiol Rev. 2014 Nov;38(6):1126-45
pubmed: 24923554
Antimicrob Agents Chemother. 2004 Oct;48(10):3670-6
pubmed: 15388418
Math Med Biol. 2005 Jun;22(2):163-86
pubmed: 15781426
Antimicrob Agents Chemother. 2012 Nov;56(11):5458-64
pubmed: 22869559
PLoS Pathog. 2009 Aug;5(8):e1000541
pubmed: 19662169
Antimicrob Agents Chemother. 1994 Nov;38(11):2623-7
pubmed: 7872758
Biochemistry. 2014 Mar 18;53(10):1565-74
pubmed: 24576155
Sci Rep. 2016 Dec 13;6:38828
pubmed: 27958314
Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12106-11
pubmed: 9342370
Antimicrob Agents Chemother. 2010 Aug;54(8):3414-26
pubmed: 20516272
Nat Microbiol. 2016 Jun 20;1(7):16077
pubmed: 27572972
Antimicrob Agents Chemother. 2000 Mar;44(3):682-7
pubmed: 10681338
Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11801-5
pubmed: 8524852
Elife. 2016 Nov 17;5:
pubmed: 27852437
Mol Syst Biol. 2015 Mar;11(3):796
pubmed: 26146675
Diagn Microbiol Infect Dis. 1998 Feb;30(2):103-7
pubmed: 9554177
Elife. 2019 Aug 28;8:
pubmed: 31456563
Cell. 2018 Feb 8;172(4):758-770.e14
pubmed: 29425492
Nat Rev Genet. 2019 Jun;20(6):356-370
pubmed: 30886350
J Antimicrob Chemother. 2003 Jul;52(1):11-7
pubmed: 12805267
J Bacteriol. 1968 Sep;96(3):652-9
pubmed: 4895049
Antimicrob Agents Chemother. 2019 Sep 23;63(10):
pubmed: 31383667
Curr Top Med Chem. 2009;9(11):981-98
pubmed: 19747119
Bull Math Biol. 2013 Aug;75(8):1304-50
pubmed: 23292359
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16169-74
pubmed: 24046367
Curr Opin Biotechnol. 2017 Aug;46:90-97
pubmed: 28292709
Sci Rep. 2020 Feb 24;10(1):3282
pubmed: 32094499
Angew Chem Int Ed Engl. 2013 Aug 19;52(34):8908-11
pubmed: 23832572
Nat Commun. 2016 Dec 12;7:13766
pubmed: 27941811
Nat Chem Biol. 2015 Mar;11(3):182-8
pubmed: 25689336
J Evol Biol. 2014 May;27(5):840-53
pubmed: 24720850
Environ Microbiol. 2011 Sep;13(9):2416-34
pubmed: 21410622
PLoS Biol. 2015 Nov 18;13(11):e1002299
pubmed: 26581035
EcoSal Plus. 2012 Nov;5(1):
pubmed: 26442826
PLoS Comput Biol. 2007 Mar 16;3(3):e41
pubmed: 17367202
Sci Transl Med. 2015 May 13;7(287):287ra73
pubmed: 25972005
Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):559-64
pubmed: 9012823
Nat Rev Mol Cell Biol. 2010 Oct;11(10):728-38
pubmed: 20861881

Auteurs

Nikola Ojkic (N)

SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.

Elin Lilja (E)

SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.

Susana Direito (S)

SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.

Angela Dawson (A)

SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.

Rosalind J Allen (RJ)

SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Centre for Synthetic and Systems Biology, Edinburgh, United Kingdom.

Bartlomiej Waclaw (B)

SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom bwaclaw@googlemail.com.
Centre for Synthetic and Systems Biology, Edinburgh, United Kingdom.
ORCID: 0000-0001-5355-7994

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › A Roadblock-and-Kill Mechanism of Action Model...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Fluoroquinolones › Ciprofloxacine › A Roadblock-and-Kill Mechanism of Action Model...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › A Roadblock-and-Kill Mechanism of Action Model...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › DNA gyrase › A Roadblock-and-Kill Mechanism of Action Model...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › DNA topoisomerase IV › A Roadblock-and-Kill Mechanism of Action Model...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › DNA topoisomerases › ADN topoisomérases de type II › A Roadblock-and-Kill Mechanism of Action Model...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN bactérien › A Roadblock-and-Kill Mechanism of Action Model...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › A Roadblock-and-Kill Mechanism of Action Model...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Fluoroquinolones › A Roadblock-and-Kill Mechanism of Action Model...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › A Roadblock-and-Kill Mechanism of Action Model...